Transplantation of Autologous Mesenchymal Stem Cells for End-Stage Liver Cirrhosis: A Meta-Analysis Based on Seven Controlled Trials
المؤلفون المشاركون
Ma, Xiang-Rui
Tang, Ya-Ling
Xuan, Ming
Chang, Zheng
Wang, Xiao-Yi
Liang, Xin-Hua
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-15
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
The bone marrow-derived mesenchymal stem cells (BM-MSCs) have demonstrated great potential as regenerative medicine in different therapeutic applications.
This study aims to pool previous controlled clinical trials to make an update assessment of the effectiveness of BM-MSC transplantation on end-stage liver cirrhosis.
Methods.
Relevant studies published between January 1990 and June 2014 were searched among Pubmed, Embase, and ClinicalTrial.gov.
A meta-analysis was performed to assess the effect of BM-MSCs on liver function indicators, including Models of End-Stage Liver Disease (MELD) score, serum albumin (g/L), total bilirubin (mg/dl), Prothrombin concentration (%), and alanine aminotransferase (ALT) (U/L).
Results.
BM-MSCs therapy could significantly improve liver function in patients with end-stage liver cirrhosis, in terms of MELD score, serum albumin, total bilirubin, and prothrombin concentration, at least during the half year after transplantation.
Conclusions.
Due to BM-MSCs’ immunomodulatory functions and the potential to differentiate into hepatocytes, they are a promising therapeutic agent to liver cirrhosis.
Considering currently available evidence, this therapy is relatively safe and effective in improving liver function.
However, how different variables should be controlled to optimize the therapeutic effect is still not clear.
Thus, future mechanism studies and clinical trials are required for this optimization.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ma, Xiang-Rui& Tang, Ya-Ling& Xuan, Ming& Chang, Zheng& Wang, Xiao-Yi& Liang, Xin-Hua. 2015. Transplantation of Autologous Mesenchymal Stem Cells for End-Stage Liver Cirrhosis: A Meta-Analysis Based on Seven Controlled Trials. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1064148
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ma, Xiang-Rui…[et al.]. Transplantation of Autologous Mesenchymal Stem Cells for End-Stage Liver Cirrhosis: A Meta-Analysis Based on Seven Controlled Trials. Gastroenterology Research and Practice No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1064148
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ma, Xiang-Rui& Tang, Ya-Ling& Xuan, Ming& Chang, Zheng& Wang, Xiao-Yi& Liang, Xin-Hua. Transplantation of Autologous Mesenchymal Stem Cells for End-Stage Liver Cirrhosis: A Meta-Analysis Based on Seven Controlled Trials. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1064148
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1064148
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر