Vitamin D and Alzheimer’s Disease: Neurocognition to Therapeutics
المؤلفون المشاركون
Chakrabarti, Sasanka
Banerjee, Anindita
Ganguly, Anirban
Roy, Debashree
Ganguly, Upasana
Khemka, Vineet Kumar
المصدر
International Journal of Alzheimer's Disease
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-17
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Alzheimer’s disease (AD), the major cause of dementia worldwide, is characterized by progressive loss of memory and cognition.
The sporadic form of AD accounts for nearly 90% of the patients developing this disease.
The last century has witnessed significant research to identify various mechanisms and risk factors contributing to the complex etiopathogenesis of AD by analyzing postmortem AD brains and experimenting with animal and cell culture based models.
However, the treatment strategies, as of now, are only symptomatic.
Accumulating evidences suggested a significant association between vitamin D deficiency, dementia, and AD.
This review encompasses the beneficial role of vitamin D in neurocognition and optimal brain health along with epidemiological evidence of the high prevalence of hypovitaminosis D among aged and AD population.
Moreover, disrupted signaling, altered utilization of vitamin D, and polymorphisms of several related genes including vitamin D receptor (VDR) also predispose to AD or AD-like neurodegeneration.
This review explores the relationship between this gene-environmental influence and long term vitamin D deficiency as a risk factor for development of sporadic AD along with the role and rationale of therapeutic trials with vitamin D.
It is, therefore, urgently warranted to further establish the role of this potentially neuroprotective vitamin in preventing and halting progressive neurodegeneration in AD patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Banerjee, Anindita& Khemka, Vineet Kumar& Ganguly, Anirban& Roy, Debashree& Ganguly, Upasana& Chakrabarti, Sasanka. 2015. Vitamin D and Alzheimer’s Disease: Neurocognition to Therapeutics. International Journal of Alzheimer's Disease،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1064462
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Banerjee, Anindita…[et al.]. Vitamin D and Alzheimer’s Disease: Neurocognition to Therapeutics. International Journal of Alzheimer's Disease No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1064462
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Banerjee, Anindita& Khemka, Vineet Kumar& Ganguly, Anirban& Roy, Debashree& Ganguly, Upasana& Chakrabarti, Sasanka. Vitamin D and Alzheimer’s Disease: Neurocognition to Therapeutics. International Journal of Alzheimer's Disease. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1064462
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1064462
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر