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17β Estradiol Modulates Perfusion Pressure and Expression of 5-LOX and CYP450 4A in the Isolated Kidney of Metabolic Syndrome Female Rats
المؤلفون المشاركون
Zuñiga-Muñoz, Alejandra
Guarner Lans, Verónica
Díaz-Díaz, Eulises
Pérez-Torres, Israel
Soria-Castro, E.
Torrico-Lavayen, R.
Tena-Betancourt, E.
المصدر
International Journal of Endocrinology
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-09-27
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Prevalence of metabolic syndrome and progression of nephropathy depend on sex.
We examined a protective effect of estradiol against nephropathy in metabolic syndrome through the modulation of the arachidonic acid metabolism by activating the 5-lipoxygenase and cytochrome p450 4A pathways.
28 female Wistar rats were divided into four groups of seven animals each: control, intact metabolic syndrome, ovariectomized metabolic syndrome, and metabolic syndrome ovariectomized plus estradiol.
Blood pressure, body weight, body fat, triglycerides, insulin, HOMA-index, albuminuria, and TNF- α were increased in ovariectomized metabolic syndrome rats ( p < 0.001 ).
The perfusion pressure in isolated kidneys of ovariectomized metabolic syndrome rats in presence of 4 μ g of arachidonic acid was increased.
The inhibitors of the arachidonic acid metabolism Baicalein, Miconazole, and Indomethacin in these rats decreased the perfusion pressure by 57.62%, 99.83%, and 108.5%, respectively and they decreased creatinine clearance and the arachidonic acid percentage.
Phospholipase A2 expression in the kidney of ovariectomized metabolic syndrome rats was not modified.
5-lipoxygenase was increased in metabolic syndrome ovariectomized rats while cytochrome p450 4A was decreased.
In conclusion, the loss of estradiol increases renal damage while the treatment with estradiol benefits renal function by modulating arachidonic acid metabolism through the 5-lipoxygenase and cytochrome p450 4A pathways.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zuñiga-Muñoz, Alejandra& Guarner Lans, Verónica& Soria-Castro, E.& Díaz-Díaz, Eulises& Torrico-Lavayen, R.& Tena-Betancourt, E.…[et al.]. 2015. 17β Estradiol Modulates Perfusion Pressure and Expression of 5-LOX and CYP450 4A in the Isolated Kidney of Metabolic Syndrome Female Rats. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1065567
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zuñiga-Muñoz, Alejandra…[et al.]. 17β Estradiol Modulates Perfusion Pressure and Expression of 5-LOX and CYP450 4A in the Isolated Kidney of Metabolic Syndrome Female Rats. International Journal of Endocrinology No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1065567
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zuñiga-Muñoz, Alejandra& Guarner Lans, Verónica& Soria-Castro, E.& Díaz-Díaz, Eulises& Torrico-Lavayen, R.& Tena-Betancourt, E.…[et al.]. 17β Estradiol Modulates Perfusion Pressure and Expression of 5-LOX and CYP450 4A in the Isolated Kidney of Metabolic Syndrome Female Rats. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1065567
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1065567
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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