Treatment with α-Lipoic Acid over 16 Weeks in Type 2 Diabetic Patients with Symptomatic Polyneuropathy Who Responded to Initial 4-Week High-Dose Loading
المؤلفون المشاركون
Garcia-Alcala, Hector
Santos Vichido, Celia Isabel
Islas Macedo, Silverio
Genestier-Tamborero, Christelle Nathalie
Minutti-Palacios, Marissa
Hirales Tamez, Omara
García, Carlos
Ziegler, Dan
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-04
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Effective treatment of diabetic sensorimotor polyneuropathy remains a challenge.
To assess the efficacy and safety of α-lipoic acid (ALA) over 20 weeks, we conducted a multicenter randomized withdrawal open-label study, in which 45 patients with type 2 diabetes and symptomatic polyneuropathy were initially treated with ALA (600 mg tid) for 4 weeks (phase 1).
Subsequently, responders were randomized to receive ALA (600 mg qd; n = 16 ) or to ALA withdrawal ( n = 17 ) for 16 weeks (phase 2).
During phase 1, the Total Symptom Score (TSS) decreased from 8.9 ± 1.8 points to 3.46 ± 2.0 points.
During phase 2, TSS improved from 3.7 ± 1.9 points to 2.5 ± 2.5 points in the ALA treated group ( p < 0.05 ) and remained unchanged in the ALA withdrawal group.
The use of analgesic rescue medication was higher in the ALA withdrawal group than ALA treated group ( p < 0.05 ).
In conclusion, in type 2 diabetic patients with symptomatic polyneuropathy who responded to initial 4-week high-dose (600 mg tid) administration of ALA, subsequent treatment with ALA (600 mg qd) over 16 weeks improved neuropathic symptoms, whereas ALA withdrawal was associated with a higher use of rescue analgesic drugs.
This trial is registered with ClinicalTrials.gov Identifier: NCT02439879.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Garcia-Alcala, Hector& Santos Vichido, Celia Isabel& Islas Macedo, Silverio& Genestier-Tamborero, Christelle Nathalie& Minutti-Palacios, Marissa& Hirales Tamez, Omara…[et al.]. 2015. Treatment with α-Lipoic Acid over 16 Weeks in Type 2 Diabetic Patients with Symptomatic Polyneuropathy Who Responded to Initial 4-Week High-Dose Loading. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067851
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Garcia-Alcala, Hector…[et al.]. Treatment with α-Lipoic Acid over 16 Weeks in Type 2 Diabetic Patients with Symptomatic Polyneuropathy Who Responded to Initial 4-Week High-Dose Loading. Journal of Diabetes Research No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1067851
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Garcia-Alcala, Hector& Santos Vichido, Celia Isabel& Islas Macedo, Silverio& Genestier-Tamborero, Christelle Nathalie& Minutti-Palacios, Marissa& Hirales Tamez, Omara…[et al.]. Treatment with α-Lipoic Acid over 16 Weeks in Type 2 Diabetic Patients with Symptomatic Polyneuropathy Who Responded to Initial 4-Week High-Dose Loading. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067851
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1067851
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر