Glucocorticoid-Induced Tumour Necrosis Factor Receptor-Related Protein: A Key Marker of Functional Regulatory T Cells
المؤلفون المشاركون
Ronchetti, Simona
Ricci, Erika
Cari, Luigi
Migliorati, Graziella
Nocentini, Giuseppe
Riccardi, Carlo
Petrillo, Maria Grazia
المصدر
Journal of Immunology Research
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-15
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Glucocorticoid-induced tumour necrosis factor receptor-related protein (GITR, TNFRSF18, and CD357) is expressed at high levels in activated T cells and regulatory T cells (Tregs).
In this review, we present data from mouse and human studies suggesting that GITR is a crucial player in the differentiation of thymic Tregs (tTregs), and expansion of both tTregs and peripheral Tregs (pTregs).
The role of GITR in Treg expansion is confirmed by the association of GITR expression with markers of memory T cells.
In this context, it is not surprising that GITR appears to be a marker of active Tregs, as suggested by the association of GITR expression with other markers of Treg activation or cytokines with suppressive activity (e.g., IL-10 and TGF-β), the presence of GITR+ cells in tissues where Tregs are active (e.g., solid tumours), or functional studies on Tregs.
Furthermore, some Treg subsets including Tr1 cells express either low or no classical Treg markers (e.g., FoxP3 and CD25) and do express GITR.
Therefore, when evaluating changes in the number of Tregs in human diseases, GITR expression must be evaluated.
Moreover, GITR should be considered as a marker for isolating Tregs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ronchetti, Simona& Ricci, Erika& Petrillo, Maria Grazia& Cari, Luigi& Migliorati, Graziella& Nocentini, Giuseppe…[et al.]. 2015. Glucocorticoid-Induced Tumour Necrosis Factor Receptor-Related Protein: A Key Marker of Functional Regulatory T Cells. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1068385
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ronchetti, Simona…[et al.]. Glucocorticoid-Induced Tumour Necrosis Factor Receptor-Related Protein: A Key Marker of Functional Regulatory T Cells. Journal of Immunology Research No. 2015 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1068385
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ronchetti, Simona& Ricci, Erika& Petrillo, Maria Grazia& Cari, Luigi& Migliorati, Graziella& Nocentini, Giuseppe…[et al.]. Glucocorticoid-Induced Tumour Necrosis Factor Receptor-Related Protein: A Key Marker of Functional Regulatory T Cells. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1068385
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068385
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر