Secretion of S100A8, S100A9, and S100A12 by Neutrophils Involves Reactive Oxygen Species and Potassium Efflux
المؤلفون المشاركون
Tardif, Mélanie R.
Chapeton-Montes, Julie Andrea
Posvandzic, Alma
Pagé, Nathalie
Gilbert, Caroline
Tessier, Philippe A.
المصدر
Journal of Immunology Research
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-30
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
S100A8/A9 (calprotectin) and S100A12 proinflammatory mediators are found at inflammatory sites and in the serum of patients with inflammatory or autoimmune diseases.
These cytoplasmic proteins are secreted by neutrophils at sites of inflammation via alternative secretion pathways of which little is known.
This study examined the nature of the stimuli leading to S100A8/A9 and S100A12 secretion as well as the mechanism involved in this alternative secretion pathway.
Chemotactic agents, cytokines, and particulate molecules were used to stimulate human neutrophils.
MSU crystals, PMA, and H2O2 induced the release of S100A8, S100A9, and S100A12 homodimers, as well as S100A8/A9 heterodimer.
High concentrations of S100A8/A9 and S100A12 were secreted in response to nanoparticles like MSU, silica, TiO2, fullerene, and single-wall carbon nanotubes as well as in response to microbe-derived molecules, such as zymosan or HKCA.
However, neutrophils exposed to the chemotactic factors fMLP failed to secrete S100A8/A9 or S100A12.
Secretion of S100A8/A9 was dependent on the production of reactive oxygen species and required K+ exchanges through the ATP-sensitive K+ channel.
Altogether, these findings suggest that S100A12 and S100A8/A9 are secreted independently either via distinct mechanisms of secretion or following the activation of different signal transduction pathways.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tardif, Mélanie R.& Chapeton-Montes, Julie Andrea& Posvandzic, Alma& Pagé, Nathalie& Gilbert, Caroline& Tessier, Philippe A.. 2015. Secretion of S100A8, S100A9, and S100A12 by Neutrophils Involves Reactive Oxygen Species and Potassium Efflux. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1068433
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tardif, Mélanie R.…[et al.]. Secretion of S100A8, S100A9, and S100A12 by Neutrophils Involves Reactive Oxygen Species and Potassium Efflux. Journal of Immunology Research No. 2015 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1068433
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tardif, Mélanie R.& Chapeton-Montes, Julie Andrea& Posvandzic, Alma& Pagé, Nathalie& Gilbert, Caroline& Tessier, Philippe A.. Secretion of S100A8, S100A9, and S100A12 by Neutrophils Involves Reactive Oxygen Species and Potassium Efflux. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1068433
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068433
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر