Gingiva Equivalents Secrete Negligible Amounts of Key Chemokines Involved in Langerhans Cell Migration Compared to Skin Equivalents
المؤلفون المشاركون
de Gruijl, Tanja D.
Kosten, Ilona J.
Buskermolen, Jeroen K.
Spiekstra, Sander W.
Gibbs, Susan
المصدر
Journal of Immunology Research
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-11
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Both oral mucosa and skin have the capacity to maintain immune homeostasis or regulate immune responses upon environmental assault.
Whereas much is known about key innate immune events in skin, little is known about oral mucosa.
Comparative studies are limited due to the scarce supply of oral mucosa for ex vivo studies.
Therefore, we used organotypic tissue equivalents (reconstructed epithelium on fibroblast-populated collagen hydrogel) to study cross talk between cells.
Oral mucosa and skin equivalents were compared regarding secretion of cytokines and chemokines involved in LC migration and general inflammation.
Basal secretion, representative of homeostasis, and also secretion after stimulation with TNFα, an allergen (cinnamaldehyde), or an irritant (SDS) were assessed.
We found that proinflammatory IL-18 and chemokines CCL2, CCL20, and CXCL12, all involved in LC migration, were predominantly secreted by skin as compared to gingiva.
Furthermore, CCL27 was predominantly secreted by skin whereas CCL28 was predominantly secreted by gingiva.
In contrast, general inflammatory cytokines IL-6 and CXCL8 were secreted similarly by skin and gingiva.
These results indicate that the cytokines and chemokines triggering innate immunity and LC migration are different in skin and gingiva.
This differential regulation should be figured into novel therapy or vaccination strategies in the context of skin versus mucosa.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kosten, Ilona J.& Buskermolen, Jeroen K.& Spiekstra, Sander W.& de Gruijl, Tanja D.& Gibbs, Susan. 2015. Gingiva Equivalents Secrete Negligible Amounts of Key Chemokines Involved in Langerhans Cell Migration Compared to Skin Equivalents. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1068536
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kosten, Ilona J.…[et al.]. Gingiva Equivalents Secrete Negligible Amounts of Key Chemokines Involved in Langerhans Cell Migration Compared to Skin Equivalents. Journal of Immunology Research No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1068536
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kosten, Ilona J.& Buskermolen, Jeroen K.& Spiekstra, Sander W.& de Gruijl, Tanja D.& Gibbs, Susan. Gingiva Equivalents Secrete Negligible Amounts of Key Chemokines Involved in Langerhans Cell Migration Compared to Skin Equivalents. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1068536
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068536
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر