Prophylactic mRNA Vaccination against Allergy Confers Long-Term Memory Responses and Persistent Protection in Mice
المؤلفون المشاركون
Weiss, Richard
Hattinger, E.
Scheiblhofer, S.
Roesler, E.
Thalhamer, T.
Thalhamer, J.
المصدر
Journal of Immunology Research
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-18
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Recently, mRNA vaccines have been introduced as a safety-optimized alternative to plasmid DNA-based vaccines for protection against allergy.
However, it remained unclear whether the short persistence of this vaccine type would limit memory responses and whether the protective immune response type would be maintained during recurrent exposure to allergen.
We tested the duration of protective memory responses in mice vaccinated with mRNA encoding the grass pollen allergen Phl p 5 by challenging them with recombinant allergen, 3.5, 6, and 9 months after vaccination.
In a second experiment, vaccinated mice were repeatedly challenged monthly with aerosolized allergen over a period of 7 months.
Antibody and cytokine responses as well as lung inflammation and airway hyperresponsiveness were assessed.
mRNA vaccination induced robust TH1 memory responses for at least 9 months.
Vaccination efficiently suppressed TH2 cytokines, IgE responses, and lung eosinophilia.
Protection was maintained after repeated exposure to aerosolized allergen and no TH1 associated pathology was observed.
Lung function remained improved compared to nonvaccinated controls.
Our data clearly indicate that mRNA vaccination against Phl p 5 induces robust, long-lived memory responses, which can be recalled by allergen exposure without side effects.
mRNA vaccines fulfill the requirements for safe prophylactic vaccination without the need for booster immunizations.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hattinger, E.& Scheiblhofer, S.& Roesler, E.& Thalhamer, T.& Thalhamer, J.& Weiss, Richard. 2015. Prophylactic mRNA Vaccination against Allergy Confers Long-Term Memory Responses and Persistent Protection in Mice. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1068600
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hattinger, E.…[et al.]. Prophylactic mRNA Vaccination against Allergy Confers Long-Term Memory Responses and Persistent Protection in Mice. Journal of Immunology Research No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1068600
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hattinger, E.& Scheiblhofer, S.& Roesler, E.& Thalhamer, T.& Thalhamer, J.& Weiss, Richard. Prophylactic mRNA Vaccination against Allergy Confers Long-Term Memory Responses and Persistent Protection in Mice. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1068600
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068600
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر