The Novel Functions of the PLCPKCPKD Signaling Axis in G Protein-Coupled Receptor-Mediated Chemotaxis of Neutrophils

الملخص EN

Chemotaxis, a directional cell migration guided by extracellular chemoattractant gradients, plays an essential role in the recruitment of neutrophils to sites of inflammation.

Chemotaxis is mediated by the G protein-coupled receptor (GPCR) signaling pathway.

Extracellular stimuli trigger activation of the PLC/PKC/PKD signaling axis, which controls several signaling pathways.

Here, we concentrate on the novel functions of PLC/PKC/PKD signaling in GPCR-mediated chemotaxis of neutrophils.