DC-Based Immunotherapy Combined with Low-Dose Methotrexate Effective in the Treatment of Advanced CIA in Mice
المؤلفون المشاركون
Park, Jun-Eui
Jang, Jinah
Choi, Ji-Hye
Kang, Mi-sun
Woo, Yun-Ju
Seong, Young-Rim
Choi, Chan-Bum
Bae, Yong-Soo
Lee, Hye-Soon
Bae, Sang-Cheol
المصدر
Journal of Immunology Research
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-28
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
We have previously demonstrated that semimature dendritic cell- (smDC-) based immunotherapy is effective for the treatment of collagen-induced arthritis (CIA) prior to disease onset.
In the present study, we examined the efficacy of combination therapy with smDCs and methotrexate (MTX) in advanced CIA with a score of 2-3.
Combination therapy with low-dose MTX and type II collagen- (CII-) pulsed smDCs (CII-smDCs) was more effective in inhibiting disease progression than high or low-dose MTX alone or a combination of high dose MTX and CII-smDCs.
The effect of CII-smDCs alone was also comparable to the combination therapy.
CD4+Foxp3+ Treg populations and IL-10 secretion markedly increased, and CII-specific autoreactive T cells decreased in mice treated with CII-smDCs alone or in combination with MTX.
Combination therapy reduced the secretion of interferon-γ (IFN-γ) and IL-17 with little influence on the IL-4 secretion in the mixed leukocyte reaction.
These results imply that the combination therapy with low-dose MTX and smDCs is effective in controlling advanced CIA by enhancing Treg population and suppresses antigen-specific Th1/Th17 immunity, rather than initiating Th1 to Th2 immune deviation.
Our findings provide a better understanding of the DC therapy in combination with MTX for the treatment of patients with rheumatoid arthritis (RA).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Park, Jun-Eui& Jang, Jinah& Choi, Ji-Hye& Kang, Mi-sun& Woo, Yun-Ju& Seong, Young-Rim…[et al.]. 2015. DC-Based Immunotherapy Combined with Low-Dose Methotrexate Effective in the Treatment of Advanced CIA in Mice. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1068609
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Park, Jun-Eui…[et al.]. DC-Based Immunotherapy Combined with Low-Dose Methotrexate Effective in the Treatment of Advanced CIA in Mice. Journal of Immunology Research No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1068609
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Park, Jun-Eui& Jang, Jinah& Choi, Ji-Hye& Kang, Mi-sun& Woo, Yun-Ju& Seong, Young-Rim…[et al.]. DC-Based Immunotherapy Combined with Low-Dose Methotrexate Effective in the Treatment of Advanced CIA in Mice. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1068609
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068609
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر