The Interplay between Zinc, Vitamin D and, IL-17 in Patients with Chronic Hepatitis C Liver Disease
المؤلفون المشاركون
Reda, Randa
Abbas, Amal A.
Mohammed, Mai
El Fedawy, Shahira F.
Ghareeb, Hala
El Kabarity, Rania H.
Abo-Shady, Rania A.
Zakaria, Doaa
المصدر
Journal of Immunology Research
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-04
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Objectives.
To assess zinc (Zn) and vitamin D (Vit.
D) status in chronic Hepatitis C virus- (HCV) infected patients and their relationship to interleukin- (IL-) 17 and disease severity and then investigate whether Zn and Vit.
D3 modulate IL-17 expression in chronic HCV patients.
Methods.
Seventy patients and fifty healthy subjects were investigated.
Serum levels of Zn, Vit.
D, and IL-17 were assessed in the patients group and subgroups.
Patients lymphocytes were activated in vitro in the presence or absence of Zn or Vit.
D3 and then intracellular IL-17 production was assessed using flow cytometry.
Results.
Zn and Vit.
D were significantly decreased in HCV patients.
Increasing disease severity leads to more reduction in Zn level opposed by increasing IL-17 level.
Zn potently reduced IL-17 production in a dose-related fashion; however it did not exert any toxic effects.
Although Vit.
D apparently increases IL17 expression, it is unclear whether it is due to its toxic effect on cell count or lack of definite association between Vit.
D and both IL-17 and disease severity.
Conclusions.
This study demonstrates that Zn modulates IL-17 expression and provides a rationale for evaluating this compound as a supplementary agent in the treatment of chronic HCV.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Reda, Randa& Abbas, Amal A.& Mohammed, Mai& El Fedawy, Shahira F.& Ghareeb, Hala& El Kabarity, Rania H.…[et al.]. 2015. The Interplay between Zinc, Vitamin D and, IL-17 in Patients with Chronic Hepatitis C Liver Disease. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1068615
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Reda, Randa…[et al.]. The Interplay between Zinc, Vitamin D and, IL-17 in Patients with Chronic Hepatitis C Liver Disease. Journal of Immunology Research No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1068615
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Reda, Randa& Abbas, Amal A.& Mohammed, Mai& El Fedawy, Shahira F.& Ghareeb, Hala& El Kabarity, Rania H.…[et al.]. The Interplay between Zinc, Vitamin D and, IL-17 in Patients with Chronic Hepatitis C Liver Disease. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1068615
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068615
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر