Alterations of the Murine Gut Microbiome with Age and Allergic Airway Disease
المؤلفون المشاركون
Vital, Marius
Harkema, Jack R.
Rizzo, Mike
Tiedje, James
Brandenberger, Christina
المصدر
Journal of Immunology Research
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-18
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The gut microbiota plays an important role in the development of asthma.
With advanced age the microbiome and the immune system are changing and, currently, little is known about how these two factors contribute to the development of allergic asthma in the elderly.
In this study we investigated the associations between the intestinal microbiome and allergic airway disease in young and old mice that were sensitized and challenged with house dust mite (HDM).
After challenge, the animals were sacrificed, blood serum was collected for cytokine analysis, and the lungs were processed for histopathology.
Fecal pellets were excised from the colon and subjected to 16S rRNA analysis.
The microbial community structure changed with age and allergy development, where alterations in fecal communities from young to old mice resembled those after HDM challenge.
Allergic mice had induced serum levels of IL-17A and old mice developed a greater allergic airway response compared to young mice.
This study demonstrates that the intestinal bacterial community structure differs with age, possibly contributing to the exaggerated pulmonary inflammatory response in old mice.
Furthermore, our results show that the composition of the gut microbiota changes with pulmonary allergy, indicating bidirectional gut-lung communications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vital, Marius& Harkema, Jack R.& Rizzo, Mike& Tiedje, James& Brandenberger, Christina. 2015. Alterations of the Murine Gut Microbiome with Age and Allergic Airway Disease. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068628
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vital, Marius…[et al.]. Alterations of the Murine Gut Microbiome with Age and Allergic Airway Disease. Journal of Immunology Research No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1068628
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vital, Marius& Harkema, Jack R.& Rizzo, Mike& Tiedje, James& Brandenberger, Christina. Alterations of the Murine Gut Microbiome with Age and Allergic Airway Disease. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068628
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068628
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر