Therapeutic Potential of Inorganic Nanoparticles for the Delivery of Monoclonal Antibodies
المؤلفون المشاركون
Voelcker, Nicolas H.
Cowin, Allison J.
Turner, Christopher T.
McInnes, Steven J. P.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-01
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Monoclonal antibodies (mAbs), available for a range of diseases, including tumours, leukemia, and multiple sclerosis, are emerging as the fastest growing area of therapeutic drug development.
The greatest advantage of therapeutic mAbs is their ability to bind with a high degree of specificity to target proteins involved in disease pathophysiology.
In response, effector functions are triggered and these ameliorate the disease cascade.
As an alternative to this reliance on effector functions, drugs can be conjugated to mAbs.
The ability to target compounds to the site of pathology minimises the nonspecific side effects associated with systemic administration.
In both instances, optimising the delivery, absorption, and distribution of the mAbs, whilst minimising potential side effects, remain the key hurdles to improved clinical outcomes.
Novel delivery strategies are being investigated with more vigour in recent years, and nanoparticles are being identified as suitable vehicles.
In conjunction with permitting a controlled release profile, nanoparticles protect the drug from degradation, reducing both the dose and frequency of administration.
Moreover, these particles shield the patient from the immune complications associated with high dose mAb infusions or drug cytotoxicity.
This review outlines recent advances in nanoparticle technology and how they may be of benefit as therapeutic mAb delivery/targeting vehicles.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Turner, Christopher T.& McInnes, Steven J. P.& Voelcker, Nicolas H.& Cowin, Allison J.. 2015. Therapeutic Potential of Inorganic Nanoparticles for the Delivery of Monoclonal Antibodies. Journal of Nanomaterials،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1068908
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Turner, Christopher T.…[et al.]. Therapeutic Potential of Inorganic Nanoparticles for the Delivery of Monoclonal Antibodies. Journal of Nanomaterials No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1068908
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Turner, Christopher T.& McInnes, Steven J. P.& Voelcker, Nicolas H.& Cowin, Allison J.. Therapeutic Potential of Inorganic Nanoparticles for the Delivery of Monoclonal Antibodies. Journal of Nanomaterials. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1068908
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068908
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر