T Regulatory and T Helper 17 Cells in Primary Sjögren’s Syndrome: Facts and Perspectives
المؤلفون المشاركون
Carubbi, Francesco
Bartoloni, Elena
Mirabelli, Giulia
Cannarile, Francesca
Cipriani, Paola
Giacomelli, Roberto
Gerli, Roberto
Caterbi, Sara
Alunno, Alessia
Bistoni, Onelia
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-28
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Historically, primary Sjögren’s syndrome (pSS) was thought to be a T helper (h) 1 driven disease due to the predominance of CD4+T lymphocytes and their products in target organs and peripheral blood of patients.
In the last decades, the identification of a number of T cell subsets, including Th17, T regulatory (Treg), and follicular helper T cells, challenged this long-standing paradigm and prompted to identify their role in pSS pathogenesis.
In addition the impact of abnormal proinflammatory cytokine production, such as IL-6, IL-17, IL-22, and IL-23, has also attracted considerable attention.
However, although several studies have been carried out in experimental models and patients with pSS, many aspects concerning the role of Treg cells and IL-17/Th17 cell system in pSS pathogenesis are not fully elucidated.
In particular, the role played by different IL-17-producing T cell subsets as well as the effects of pharmacological therapies on Treg/Th17 cell balance represents an intriguing issue.
The aim of this review article is to provide an overview of current knowledge on Treg cells and IL-17-producing T cells in pSS pathogenesis.
We believe that these insights into pSS pathogenesis may provide the basis for successful therapeutic intervention in this disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Alunno, Alessia& Carubbi, Francesco& Bistoni, Onelia& Caterbi, Sara& Bartoloni, Elena& Mirabelli, Giulia…[et al.]. 2015. T Regulatory and T Helper 17 Cells in Primary Sjögren’s Syndrome: Facts and Perspectives. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072198
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Alunno, Alessia…[et al.]. T Regulatory and T Helper 17 Cells in Primary Sjögren’s Syndrome: Facts and Perspectives. Mediators of Inflammation No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1072198
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Alunno, Alessia& Carubbi, Francesco& Bistoni, Onelia& Caterbi, Sara& Bartoloni, Elena& Mirabelli, Giulia…[et al.]. T Regulatory and T Helper 17 Cells in Primary Sjögren’s Syndrome: Facts and Perspectives. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072198
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072198
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر