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Response to Infliximab in Crohn’s Disease: Genetic Analysis Supporting Expression Profile
المؤلفون المشاركون
Medrano, Luz María
Taxonera, Carlos
González-Artacho, Cristina
Pascual, Virginia
Gómez-García, María
Barreiro-de Acosta, Manuel
Pérez-Calle, José L.
Bermejo, Fernando
López-Sanromán, Antonio
Martín Arranz, Dolores
Gisbert, Javier P.
Mendoza, Juan Luis
Núñez, Concepción
Urcelay, Elena
Martin, Javier
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-03
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Substantial proportion of Crohn’s disease (CD) patients shows no response or a limited response to treatment with infliximab (IFX) and to identify biomarkers of response would be of great clinical and economic benefit.
The expression profile of five genes (S100A8-S100A9, G0S2, TNFAIP6, and IL11) reportedly predicted response to IFX and we aimed at investigating their etiologic role through genetic association analysis.
Patients with active CD (350) who received at least three induction doses of IFX were included and classified according to IFX response.
A tagging strategy was used to select genetic polymorphisms that cover the variability present in the chromosomal regions encoding the identified genes with altered expression.
Following genotyping, differences between responders and nonresponders to IFX were observed in haplotypes of the studied regions: S100A8-S100A9 (rs11205276*G/rs3014866*C/rs724781*C/rs3006488*A; P=0.05); G0S2 (rs4844486*A/rs1473683*T; P=0.15); TNFAIP6 (rs11677200*C/rs2342910*A/rs3755480*G/rs10432475*A; P=0.10); and IL11 (rs1126760*C/rs1042506*G; P=0.07).
These differences were amplified in patients with colonic and ileocolonic location for all but the TNFAIP6 haplotype, which evidenced significant difference in ileal CD patients.
Our results support the role of the reported expression signature as predictive of anti-TNF outcome in CD patients and suggest an etiological role of those top-five genes in the IFX response pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Medrano, Luz María& Taxonera, Carlos& González-Artacho, Cristina& Pascual, Virginia& Gómez-García, María& Barreiro-de Acosta, Manuel…[et al.]. 2015. Response to Infliximab in Crohn’s Disease: Genetic Analysis Supporting Expression Profile. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1072246
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Medrano, Luz María…[et al.]. Response to Infliximab in Crohn’s Disease: Genetic Analysis Supporting Expression Profile. Mediators of Inflammation No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1072246
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Medrano, Luz María& Taxonera, Carlos& González-Artacho, Cristina& Pascual, Virginia& Gómez-García, María& Barreiro-de Acosta, Manuel…[et al.]. Response to Infliximab in Crohn’s Disease: Genetic Analysis Supporting Expression Profile. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1072246
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072246
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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