Airway β-Defensin-1 Protein Is Elevated in COPD and Severe Asthma
المؤلفون المشاركون
Simpson, Jodie L.
Gibson, Peter G.
Wright, Thomas K.
Wood, Lisa G.
Parsons, Kristy S.
Wark, Peter A.
Baines, Katherine J.
McDonald, Vanessa M.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-19
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Innate immune antimicrobial peptides, including β-defensin-1, promote the chemotaxis and activation of several immune cells.
The role of β-defensin-1 in asthma and chronic obstructive pulmonary disease (COPD) remains unclear.
Methods.
Induced sputum was collected from healthy controls and individuals with asthma or COPD.
β-defensin-1 protein in sputum supernatant was quantified by ELISA.
Biomarker potential was examined using receiver operating characteristic curves.
β-defensin-1 release from primary bronchial epithelial cells (pBECs) was investigated in culture with and without cigarette smoke extract (CSE).
Results.
Airway β-defensin-1 protein was elevated in COPD participants compared to asthma participants and healthy controls.
Inflammatory phenotype had no effect on β-defensin-1 levels in asthma or COPD.
β-defensin-1 protein was significantly higher in severe asthma compared to controlled and uncontrolled asthma.
β-defensin-1 protein could predict the presence of COPD from both healthy controls and asthma patients.
Exposure of pBECs to CSE decreased β-defensin-1 production in healthy controls; however in pBECs from COPD participants the level of β-defensin-1 remanied unchanged.
Conclusions.
Elevated β-defensin-1 protein is a feature of COPD and severe asthma regardless of inflammatory phenotype.
β-defensin-1 production is dysregulated in the epithelium of patients with COPD and may be an effective biomarker and potential therapeutic target.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Baines, Katherine J.& Wright, Thomas K.& Simpson, Jodie L.& McDonald, Vanessa M.& Wood, Lisa G.& Parsons, Kristy S.…[et al.]. 2015. Airway β-Defensin-1 Protein Is Elevated in COPD and Severe Asthma. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1072308
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Baines, Katherine J.…[et al.]. Airway β-Defensin-1 Protein Is Elevated in COPD and Severe Asthma. Mediators of Inflammation No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1072308
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Baines, Katherine J.& Wright, Thomas K.& Simpson, Jodie L.& McDonald, Vanessa M.& Wood, Lisa G.& Parsons, Kristy S.…[et al.]. Airway β-Defensin-1 Protein Is Elevated in COPD and Severe Asthma. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1072308
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072308
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر