Pathogenic Roles of Macrophage Migration Inhibitory Factor during Dengue Virus Infection
المؤلفون المشاركون
Yeh, Trai-Ming
Chuang, Yung-Chun
Chen, Hong-Ru
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-02
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Dengue virus (DENV) infection is the most common cause of viral hemorrhagic fever, which can lead to life-threatening dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS).
Hemorrhage and plasma leakage are two major hallmarks of DHF/DSS.
Because the mechanisms causing these pathogenic changes are unclear, there is no effective therapy against DHF/DSS.
In this review, we focus on the possible pathogenic effects of a pleiotropic cytokine, macrophage migration inhibitory factor (MIF), on the pathogenesis of DENV infection.
MIF is a critical mediator of the host immune response and inflammation, and there is a correlation between the serum levels of MIF and disease severity in dengue patients.
Furthermore, MIF knock-out mice exhibit less severe clinical disease and lethality.
However, the role of MIF in the pathogenesis of DHF/DSS is not limited to immune cell recruitment.
Recent evidence indicates that DENV infection induced MIF production and may contribute to vascular hyperpermeability and viral replication during DENV infection.
The expression of both adhesion and coagulation molecules on MIF-stimulated monocytes and endothelial cells is also increased, which may contribute to inflammatory and anticoagulatory states during DHF/DSS.
Therefore, blocking MIF production or its function may provide a solution for the treatment and prevention of DHF/DSS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chuang, Yung-Chun& Chen, Hong-Ru& Yeh, Trai-Ming. 2015. Pathogenic Roles of Macrophage Migration Inhibitory Factor during Dengue Virus Infection. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1072418
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chuang, Yung-Chun…[et al.]. Pathogenic Roles of Macrophage Migration Inhibitory Factor during Dengue Virus Infection. Mediators of Inflammation No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1072418
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chuang, Yung-Chun& Chen, Hong-Ru& Yeh, Trai-Ming. Pathogenic Roles of Macrophage Migration Inhibitory Factor during Dengue Virus Infection. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1072418
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072418
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر