IL-1 Receptor Blockade Alleviates Graft-versus-Host Disease through Downregulation of an Interleukin-1β-Dependent Glycolytic Pathway in Th17 Cells
المؤلفون المشاركون
Kim, Eun-Kyung
Cho, Mi-La
Park, Min-Jung
Lee, Seung Hoon
Lee, Sung-Hee
Lee, Eun-Jung
Choi, Jong Young
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-20
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
T helper (Th) 17 cells are a subset of Th cells expressing interleukin- (IL-) 17 and initiating an inflammatory response in autoimmune diseases.
Graft-versus-host disease (GVHD) is an immune inflammatory disease caused by interactions between the adaptive immunity of donor and recipient.
The Th17 lineage exhibits proinflammatory activity and is believed to be a central player in GVHD.
IL-1 performs a key function in immune responses and induces development of Th17 cells.
Here, we show that blockade of IL-1 signaling suppresses Th17 cell differentiation and alleviates GVHD severity.
We hypothesized that the IL-1 receptor antagonist (IL-1Ra) would suppress Th17 cell differentiation in vitro via inhibition of glycolysis-related genes.
Blockade of IL-1 using IL-1Ra downregulated Th17 cell differentiation, an alloreactive T cell response, and expression of genes of the glycolysis pathway.
Severity of GVHD was reduced in mice with a transplant of IL-Ra-treated cells, in comparison with control mice.
To clarify the mechanisms via which IL-1Ra exerts the therapeutic effect, we demonstrated in vivo that IL-1Ra decreased the proportion of Th17 cells, increased the proportion of FoxP3-expressing T regulatory (Treg) cells, and inhibited expression of glycolysis-related genes and suppressed Th17 cell development and B-cell activation.
These results suggest that blockade of IL-1 signaling ameliorates GVHD via suppression of excessive T cell-related inflammation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Park, Min-Jung& Lee, Seung Hoon& Lee, Sung-Hee& Lee, Eun-Jung& Kim, Eun-Kyung& Choi, Jong Young…[et al.]. 2015. IL-1 Receptor Blockade Alleviates Graft-versus-Host Disease through Downregulation of an Interleukin-1β-Dependent Glycolytic Pathway in Th17 Cells. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1072473
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Park, Min-Jung…[et al.]. IL-1 Receptor Blockade Alleviates Graft-versus-Host Disease through Downregulation of an Interleukin-1β-Dependent Glycolytic Pathway in Th17 Cells. Mediators of Inflammation No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1072473
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Park, Min-Jung& Lee, Seung Hoon& Lee, Sung-Hee& Lee, Eun-Jung& Kim, Eun-Kyung& Choi, Jong Young…[et al.]. IL-1 Receptor Blockade Alleviates Graft-versus-Host Disease through Downregulation of an Interleukin-1β-Dependent Glycolytic Pathway in Th17 Cells. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1072473
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072473
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر