Serum Levels of Lipopolysaccharide and 1,3-β-D-Glucan Refer to the Severity in Patients with Crohn’s Disease
المؤلفون المشاركون
Liu, Zhanju
Guo, Yanmin
Zhou, Guangxi
He, Chong
Yang, Wenjing
He, Zhenkun
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-28
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objectives.
Interactions between the host and gut microbial community contribute to the pathogenesis of Crohn’s disease (CD).
In this study, we aimed to detect lipopolysaccharide (LPS) and 1,3-β-D-glucan (BG) in the sera of CD patients and clarify the potential role in the diagnosis and therapeutic approaches.
Materials and Methods.
Serum samples were collected from 46 patients with active CD (A-CD), 22 CD patients at remission stage (R-CD), and 20 healthy controls, and the levels of LPS, BG, and TNF in sera were determined by ELISA.
Moreover, sixteen patients with A-CD received anti-TNF monoclonal antibody therapy (infliximab, IFX) at a dose of 5 mg/kg body weight at weeks 0, 2, and 6, and the levels of LPS and BG were also tested at week 12 after the first intravenous infusion.
Results.
Serum levels of LPS and BG were found to be markedly increased in A-CD patients compared with R-CD patients and healthy controls ( P < 0.05 ) .
They were also observed to be positively correlated with CDAI, ESR, and SES-CD, respectively ( P < 0.05 ) .
Furthermore, the levels of TNF in sera had a significant correlation with LPS and BG, respectively.
The concentrations of LPS and BG were demonstrated to be significantly downregulated in the sera of A-CD patients 12 weeks after IFX treatment ( P < 0.05 ) , suggesting that blockade of TNF could inhibit bacterial endotoxin absorption, partially through improving intestinal mucosal barrier.
Conclusions.
Serum levels of LPS and BG are significantly increased in A-CD patients and positively correlated with the severity of the disease.
Blockade of intestinal mucosal inflammation with IFX could reduce the levels of LPS and BG in sera.
Therefore, this study has shed some light on measurement of serum LPS and BG in the diagnosis and treatment of CD patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Guo, Yanmin& Zhou, Guangxi& He, Chong& Yang, Wenjing& He, Zhenkun& Liu, Zhanju. 2015. Serum Levels of Lipopolysaccharide and 1,3-β-D-Glucan Refer to the Severity in Patients with Crohn’s Disease. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072607
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Guo, Yanmin…[et al.]. Serum Levels of Lipopolysaccharide and 1,3-β-D-Glucan Refer to the Severity in Patients with Crohn’s Disease. Mediators of Inflammation No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1072607
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Guo, Yanmin& Zhou, Guangxi& He, Chong& Yang, Wenjing& He, Zhenkun& Liu, Zhanju. Serum Levels of Lipopolysaccharide and 1,3-β-D-Glucan Refer to the Severity in Patients with Crohn’s Disease. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072607
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072607
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر