25-OH Vitamin D and Interleukin-8: Emerging Biomarkers in Cutaneous Melanoma Development and Progression
المؤلفون المشاركون
Ene, Corina-Daniela
Anghel, Amalia-Elena
Nicolae, Ilinca
Neagu, Monica
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-04
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
There are several circulatory biomarkers that are involved in forecasting the clinical outcome of cutaneous melanoma.
Serum/plasma vitamin D status is one of the markers intensively studied in this type of cutaneous cancer.
The combination of validated serum biomarkers (like LDH) with new biomarkers such as IL-8, angiogenic factor, and vitamin D is still at the dawn of research.
Hence, we are aiming to establish the predictive power of inflammatory biomarkers, such as IL-8, and metabolic ones, such as vitamin D.
These candidate biomarkers are intended to aid classical biomarkers, such as LDH, in the prognosis of cutaneous melanoma.
Methods.
Serum vitamin D and IL-8 were quantified in melanoma patients and in matching healthy controls.
Results.
Median serum vitamin D concentrations were significantly lower (p=0.003) in melanoma patients as compared to healthy control subjects, while around 65% of the investigated patients have proven a severe circulatory deficiency of this vitamin.
IL-8 was found increased (p=0.001) in melanoma patients as compared to controls.
Conclusion.
Upregulation of proangiogenic factors associated with vitamin D deficiency can prove to be potent future biomarkers candidates, enhancing the predictive power of classical LDH.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ene, Corina-Daniela& Anghel, Amalia-Elena& Neagu, Monica& Nicolae, Ilinca. 2015. 25-OH Vitamin D and Interleukin-8: Emerging Biomarkers in Cutaneous Melanoma Development and Progression. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1072631
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ene, Corina-Daniela…[et al.]. 25-OH Vitamin D and Interleukin-8: Emerging Biomarkers in Cutaneous Melanoma Development and Progression. Mediators of Inflammation No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1072631
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ene, Corina-Daniela& Anghel, Amalia-Elena& Neagu, Monica& Nicolae, Ilinca. 25-OH Vitamin D and Interleukin-8: Emerging Biomarkers in Cutaneous Melanoma Development and Progression. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1072631
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072631
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر