Is Parkinson’s Disease Truly a Prion-Like Disorder? An Appraisal of Current Evidence
المؤلفون المشاركون
Chauhan, Aneesha
Jeans, Alexander F.
المصدر
Neurology Research International
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-01-13
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Parkinson’s disease (PD) is the world’s second most common neurodegenerative disease and most common movement disorder.
Characterised by a loss of dopaminergic neurons and the development of intraneuronal inclusions known as Lewy bodies, it has classically been thought of as a cell-autonomous disease.
However, in 2008, two groups reported the startling observation of Lewy bodies within embryonic neuronal grafts transplanted into PD patients little more than a decade previously, suggesting that PD pathology can be propagated to neighbouring cells and calling basic assumptions of our understanding of the disease into question.
Subsequent research has largely served to confirm this interpretation, pointing towards a prion-like intercellular transfer of misfolded α-synuclein, the main component of Lewy bodies, as central to PD.
This shift in thinking offers a revolutionary approach to PD treatment, potentially enabling a transition from purely symptomatic therapy to direct targeting of the pathology that drives disease progression.
In this short review, we appraise current experimental support for PD as a prion-like disease, whilst highlighting areas of controversy or inconsistency which must be resolved.
We also offer a brief discussion of the therapeutic implications of these discoveries.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chauhan, Aneesha& Jeans, Alexander F.. 2015. Is Parkinson’s Disease Truly a Prion-Like Disorder? An Appraisal of Current Evidence. Neurology Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075440
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chauhan, Aneesha& Jeans, Alexander F.. Is Parkinson’s Disease Truly a Prion-Like Disorder? An Appraisal of Current Evidence. Neurology Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1075440
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chauhan, Aneesha& Jeans, Alexander F.. Is Parkinson’s Disease Truly a Prion-Like Disorder? An Appraisal of Current Evidence. Neurology Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075440
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075440
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر