N-Acetylcysteine for Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials
المؤلفون المشاركون
Thakker, Divyesh
Patel, Isha
Walia, Rama
Raval, Amit D.
المصدر
Obstetrics and Gynecology International
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-01-08
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Objective.
To review the benefits and harms of N-acetylcysteine (NAC) in women with polycystic ovary syndrome (PCOS).
Method.
Literature search was conducted using the bibliographic databases, MEDLINE (Ovid), CINAHL, EMBASE, Scopus, PsyInfo, and PROQUEST (from inception to September 2013) for the studies on women with PCOS receiving NAC.
Results.
Eight studies with a total of 910 women with PCOS were randomized to NAC or other treatments/placebo.
There were high risk of selection, performance, and attrition bias in two studies and high risk of reporting bias in four studies.
Women with NAC had higher odds of having a live birth, getting pregnant, and ovulation as compared to placebo.
However, women with NAC were less likely to have pregnancy or ovulation as compared to metformin.
There was no significant difference in rates of the miscarriage, menstrual regulation, acne, hirsutism, and adverse events, or change in body mass index, testosterone, and insulin levels with NAC as compared to placebo.
Conclusions.
NAC showed significant improvement in pregnancy and ovulation rate as compared to placebo.
The findings need further confirmation in well-designed randomized controlled trials to examine clinical outcomes such as live birth rate in longer follow-up periods.
Systematic review registration number is CRD42012001902.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Thakker, Divyesh& Raval, Amit D.& Patel, Isha& Walia, Rama. 2015. N-Acetylcysteine for Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials. Obstetrics and Gynecology International،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1075514
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Thakker, Divyesh…[et al.]. N-Acetylcysteine for Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials. Obstetrics and Gynecology International No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1075514
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Thakker, Divyesh& Raval, Amit D.& Patel, Isha& Walia, Rama. N-Acetylcysteine for Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials. Obstetrics and Gynecology International. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1075514
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075514
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر