Novel Antioxidant Tripeptide “ACQ” Can Prevent UV-Induced Cell Death and Preserve the Number of Epidermal Stem Cells
المؤلفون المشاركون
Choi, Hye-Ryung
Na, Jung-Im
Nam, Kyung-Mi
Lee, Hyun-Sun
Shin, Jung-Won
Park, Kyoung-Chan
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-25
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
We found that tripeptide “ACQ: alanine-cysteine-glutamine” has significant DPPH scavenging activity compared to that of glutathione.
Antioxidant effects of ACQ were tested in in vitro and in vivo models.
When treated with H2O2, mock treated fibroblasts and keratinocytes showed strong staining by H2DCFA.
But, ACQ showed good protective effects against hydrogen peroxide treatment.
When mice were fed for 2 or 4 weeks, similar protective effects were observed.
In the control group, epidermis was severely damaged by UV irradiation and apoptotic keratinocytes were observed.
There were also numerous TUNEL positive cells.
But in the ACQ group, epidermis became thicker and there was no sign of severe damage.
Interestingly, the number of p63 cells was also higher in ACQ fed mice.
To confirm the stem cell rescuing effects of ACQ, three-dimensional skin samples were constructed.
Results showed that ACQ increased the expression of integrin α6 and the number of p63 positive cells.
These findings showed that ACQ has good antioxidant activity and may increase stem cell activities by the regulation of integrin α6.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Choi, Hye-Ryung& Shin, Jung-Won& Na, Jung-Im& Nam, Kyung-Mi& Lee, Hyun-Sun& Park, Kyoung-Chan. 2015. Novel Antioxidant Tripeptide “ACQ” Can Prevent UV-Induced Cell Death and Preserve the Number of Epidermal Stem Cells. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075602
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Choi, Hye-Ryung…[et al.]. Novel Antioxidant Tripeptide “ACQ” Can Prevent UV-Induced Cell Death and Preserve the Number of Epidermal Stem Cells. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1075602
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Choi, Hye-Ryung& Shin, Jung-Won& Na, Jung-Im& Nam, Kyung-Mi& Lee, Hyun-Sun& Park, Kyoung-Chan. Novel Antioxidant Tripeptide “ACQ” Can Prevent UV-Induced Cell Death and Preserve the Number of Epidermal Stem Cells. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075602
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075602
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر