The Effect of Etoricoxib on Hepatic Ischemia-Reperfusion Injury in Rats
المؤلفون المشاركون
Kunak, Celalettin Semih
Kukula, Osman
Mutlu, Emre
Genç, Fatma
Güleç Peker, Gülçer
Kuyrukluyıldız, Ufuk
Binici, Orhan
Altuner, Durdu
Alp, Hamit Hakan
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-05
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Ischemia-reperfusion (I/R) damage is known to be a pathological process which continues with the increase of oxidants and expands with the inflammatory response.
There is not any study about protective effect of etoricoxib on the liver I/R damage in literature.
Objective.
This study investigates the effect of etoricoxib on oxidative stress induced by I/R of the rat liver.
Material and Methods.
Experimental animals were divided into four groups as liver I/R control (LIRC), 50 mg/kg etoricoxib + liver I/R (ETO-50), 100 mg/kg etoricoxib + liver I/R (ETO-100), and healthy group (HG).
ETO-50 and ETO-100 groups were administered etoricoxib, while LIRC and HG groups were orally given distilled water by gavage.
Hepatic artery was clamped for one hour to provide ischemia, and then reperfusion was provided for 6 hours.
Oxidant, antioxidant, and COX-2 gene expressions were studied in the liver tissues.
ALT and AST were measured.
Results.
Etoricoxib in 50 and 100 mg/kg doses changed the levels of oxidant/antioxidant parameters such as MDA, MPO, tGSH, GSHRd, GST, SOD, NO, and 8-OH/Gua in favour of antioxidants.
Furthermore, etoricoxib prevented increase of COX-2 gene expression and ALT and AST levels.
This important protective effect of etoricoxib on the rat liver I/R can be tested in the clinical setting.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kunak, Celalettin Semih& Kukula, Osman& Mutlu, Emre& Genç, Fatma& Güleç Peker, Gülçer& Kuyrukluyıldız, Ufuk…[et al.]. 2015. The Effect of Etoricoxib on Hepatic Ischemia-Reperfusion Injury in Rats. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075702
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kunak, Celalettin Semih…[et al.]. The Effect of Etoricoxib on Hepatic Ischemia-Reperfusion Injury in Rats. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1075702
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kunak, Celalettin Semih& Kukula, Osman& Mutlu, Emre& Genç, Fatma& Güleç Peker, Gülçer& Kuyrukluyıldız, Ufuk…[et al.]. The Effect of Etoricoxib on Hepatic Ischemia-Reperfusion Injury in Rats. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075702
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075702
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر