PRMT1 and PRMT4 Regulate Oxidative Stress-Induced Retinal Pigment Epithelial Cell Damage in SIRT1-Dependent and SIRT1-Independent Manners
المؤلفون المشاركون
Han, Ho-Jae
Kim, Dong-Il
Park, Min-Jung
Choi, Joo-Hee
Kim, In-Seon
Yoon, Kyung-Chul
Park, Sang-Woo
Lee, Min-Young
Oh, Ki-Seok
Park, Soo Hyun
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-25
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Oxidative stress-induced retinal pigment epithelial (RPE) cell damage is involved in the progression of diabetic retinopathy.
Arginine methylation catalyzed by protein arginine methyltransferases (PRMTs) has emerged as an important histone modification involved in diverse diseases.
Sirtuin (SIRT1) is a protein deacetylase implicated in the onset of metabolic diseases.
Therefore, we examined the roles of type I PRMTs and their relationship with SIRT1 in human RPE cells under H2O2-induced oxidative stress.
H2O2 treatment increased PRMT1 and PRMT4 expression but decreased SIRT1 expression.
Similar to H2O2 treatment, PRMT1 or PRMT4 overexpression increased RPE cell damage.
Moreover, the H2O2-induced RPE cell damage was attenuated by PRMT1 or PRMT4 knockdown and SIRT1 overexpression.
In this study, we revealed that SIRT1 expression was regulated by PRMT1 but not by PRMT4.
Finally, we found that PRMT1 and PRMT4 expression is increased in the RPE layer of streptozotocin-treated rats.
Taken together, we demonstrated that oxidative stress induces apoptosis both via PRMT1 in a SIRT1-dependent manner and via PRMT4 in a SIRT1-independent manner.
The inhibition of the expression of type I PRMTs, especially PRMT1 and PRMT4, and increased SIRT1 could be therapeutic approaches for diabetic retinopathy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Dong-Il& Park, Min-Jung& Choi, Joo-Hee& Kim, In-Seon& Han, Ho-Jae& Yoon, Kyung-Chul…[et al.]. 2015. PRMT1 and PRMT4 Regulate Oxidative Stress-Induced Retinal Pigment Epithelial Cell Damage in SIRT1-Dependent and SIRT1-Independent Manners. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1075714
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Dong-Il…[et al.]. PRMT1 and PRMT4 Regulate Oxidative Stress-Induced Retinal Pigment Epithelial Cell Damage in SIRT1-Dependent and SIRT1-Independent Manners. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1075714
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Dong-Il& Park, Min-Jung& Choi, Joo-Hee& Kim, In-Seon& Han, Ho-Jae& Yoon, Kyung-Chul…[et al.]. PRMT1 and PRMT4 Regulate Oxidative Stress-Induced Retinal Pigment Epithelial Cell Damage in SIRT1-Dependent and SIRT1-Independent Manners. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1075714
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075714
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر