The Loss of Cellular Junctions in Epithelial Lung Cells Induced by Cigarette Smoke Is Attenuated by Corilagin
المؤلفون المشاركون
Borgatti, Monica
Gambari, Roberto
Muresan, Ximena M.
Cervellati, Franco
Sticozzi, Claudia
Belmonte, Giuseppe
Chui, Chung Hin
Lampronti, Ilaria
Giuseppe, Valacchi
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-24
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Cigarette smoke (CS) contains over 4700 compounds, many of which can affect cellular redox balance through free radicals production or through the modulation of antioxidant enzymes.
The respiratory tract is one of the organs directly exposed to CS and it is known that CS can damage the integrity of lung epithelium by affecting cell junctions and increasing epithelium permeability.
In this study, we have used a human lung epithelial cell line, Calu-3, to evaluate the effect of CS on lung epithelial cell junctions levels, with special focus on the expression of two proteins involved in intercellular communication: connexins (Cx) 40 and 43.
CS exposure increased Cx40 gene expression but not of Cx43.
CS also induced NFκB activation and the formation of 4HNE-Cxs adducts.
Since corilagin, a natural polyphenol, is able to inhibit NFκB activation, we have determined whether corilagin could counteract the effect of CS on Cxs expression.
Corilagin was able to diminish CS induced Cx40 gene expression, 4HNE-Cx40 adducts formation, and NFκB activation.
The results of this study demonstrated that CS induced the loss of cellular junctions in lung epithelium, possibly as a consequence of Cx-4HNE adducts formation, and corilagin seems to be able to abolish these CS induced alterations.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Muresan, Ximena M.& Cervellati, Franco& Sticozzi, Claudia& Belmonte, Giuseppe& Chui, Chung Hin& Lampronti, Ilaria…[et al.]. 2015. The Loss of Cellular Junctions in Epithelial Lung Cells Induced by Cigarette Smoke Is Attenuated by Corilagin. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1075718
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Muresan, Ximena M.…[et al.]. The Loss of Cellular Junctions in Epithelial Lung Cells Induced by Cigarette Smoke Is Attenuated by Corilagin. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1075718
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Muresan, Ximena M.& Cervellati, Franco& Sticozzi, Claudia& Belmonte, Giuseppe& Chui, Chung Hin& Lampronti, Ilaria…[et al.]. The Loss of Cellular Junctions in Epithelial Lung Cells Induced by Cigarette Smoke Is Attenuated by Corilagin. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1075718
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075718
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر