Dietary Tocotrienolγ-Cyclodextrin Complex Increases Mitochondrial Membrane Potential and ATP Concentrations in the Brains of Aged Mice
المؤلفون المشاركون
Schloesser, Anke
Esatbeyoglu, Tuba
Piegholdt, Stefanie
Dose, Janina
Ikuta, Naoko
Okamoto, Hinako
Ishida, Yoshiyuki
Terao, Keiji
Matsugo, Seiichi
Rimbach, Gerald
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-02
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Brain aging is accompanied by a decrease in mitochondrial function.
In vitro studies suggest that tocotrienols, including γ- and δ-tocotrienol (T3), may exhibit neuroprotective properties.
However, little is known about the effect of dietary T3 on mitochondrial function in vivo.
In this study, we monitored the effect of a dietary T3/γ-cyclodextrin complex (T3CD) on mitochondrial membrane potential and ATP levels in the brain of 21-month-old mice.
Mice were fed either a control diet or a diet enriched with T3CD providing 100 mg T3 per kg diet for 6 months.
Dietary T3CD significantly increased mitochondrial membrane potential and ATP levels compared to those of controls.
The increase in MMP and ATP due to dietary T3CD was accompanied by an increase in the protein levels of the mitochondrial transcription factor A (TFAM).
Furthermore, dietary T3CD slightly increased the mRNA levels of superoxide dismutase, γ-glutamyl cysteinyl synthetase, and heme oxygenase 1 in the brain.
Overall, the present data suggest that T3CD increases TFAM, mitochondrial membrane potential, and ATP synthesis in the brains of aged mice.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Schloesser, Anke& Esatbeyoglu, Tuba& Piegholdt, Stefanie& Dose, Janina& Ikuta, Naoko& Okamoto, Hinako…[et al.]. 2015. Dietary Tocotrienolγ-Cyclodextrin Complex Increases Mitochondrial Membrane Potential and ATP Concentrations in the Brains of Aged Mice. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075773
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Schloesser, Anke…[et al.]. Dietary Tocotrienolγ-Cyclodextrin Complex Increases Mitochondrial Membrane Potential and ATP Concentrations in the Brains of Aged Mice. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1075773
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Schloesser, Anke& Esatbeyoglu, Tuba& Piegholdt, Stefanie& Dose, Janina& Ikuta, Naoko& Okamoto, Hinako…[et al.]. Dietary Tocotrienolγ-Cyclodextrin Complex Increases Mitochondrial Membrane Potential and ATP Concentrations in the Brains of Aged Mice. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075773
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075773
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر