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Effect of GBA Mutations on Phenotype of Parkinson’s Disease: A Study on Chinese Population and a Meta-Analysis
المؤلفون المشاركون
Zhang, Yuan
Sun, Qi-ying
Zhao, Yu-wen
Shu, Li
Guo, Ji-feng
Xu, Qian
Yan, Xin-xiang
Tang, Bei-sha
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-09-02
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
GBA has been identified as a genetic risk factor for PD.
Whether the clinical manifestations of PD patients with or without GBA mutations are different has still not reached a consensus.
We firstly detected the GBA mutation L444P in 1147 Chinese PD patients and simultaneously evaluated their corresponding clinical data.
Then we compared the phenotypes between 646 PD patients with GBA mutations and 10344 PD patients without GBA mutations worldwide through meta-analysis.
Through the method of meta-analysis, there was significant difference in age at onset (MD = −3.10 [95% CI: −4.88, −1.32]), bradykinesia as an initial symptom (OR = 1.49 [95% CI: 1.15, 1.94]), having family history (OR = 1.50 [95% CI: 1.18, 1.91]), and dementia (OR = 3.21 [95% CI: 1.97, 5.24]) during the comparison between PD patients with and without GBA mutations.
While, in the aspect of tremor as an initial symptom (OR = 0.81 [95% CI: 0.64, 1.03]), the severity of motor symptoms such as H-Y (MD = 0.06 [95% CI: −0.06, 0.17]) and UPDRS-III (MD = 1.61 [95% CI: −0.65, 3.87]) and having dyskinesia (OR = 1.60 [95% CI: 0.90, 2.84]) during the comparison between the two groups revealed no statistical differences.
Our results suggested that the phenotypes of PD patients with GBA mutations are different from GBA noncarriers.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Yuan& Sun, Qi-ying& Zhao, Yu-wen& Shu, Li& Guo, Ji-feng& Xu, Qian…[et al.]. 2015. Effect of GBA Mutations on Phenotype of Parkinson’s Disease: A Study on Chinese Population and a Meta-Analysis. Parkinson’s Disease،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075923
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Yuan…[et al.]. Effect of GBA Mutations on Phenotype of Parkinson’s Disease: A Study on Chinese Population and a Meta-Analysis. Parkinson’s Disease No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1075923
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Yuan& Sun, Qi-ying& Zhao, Yu-wen& Shu, Li& Guo, Ji-feng& Xu, Qian…[et al.]. Effect of GBA Mutations on Phenotype of Parkinson’s Disease: A Study on Chinese Population and a Meta-Analysis. Parkinson’s Disease. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075923
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075923
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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