Chemical and biological studies on lemongrass leaves against nephrotoxicity in male rats

الملخص EN

The effect of different levels (10, 20 & 30% ) of lemongrass dry leaves (LEMS ) on renal dysfunction rats were evaluated.

Thirty six male albino rats 150±5 g were used in this study and divided into 6 groups (n=6).

Rats injected with 100 mg/kg b.

wt gentamicin intraperitoneally daily to induce nephrotoxicity.

The results indicated that the protective groups rats fed on LEMS levels at (10, 20 & 30% ) diets showed significant higher in feed intake (FI), body weight gain (BWG), body weight % , total protein, high density lipoprotein cholesterol (HDL-c), total antioxidants and SOD, Whereas showed significantly lower of alkaline phosphatase, albumin, uric acid, urea nitrogen, creatinine, total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-c), very low density lipoprotein cholesterol (VLDL-c) and tumor necrosis factor (TNF-α) as compared to positive control group.

The protective group at level 30% LEMS recorded and drug group with (α LA) the highest values of all parameters between all tested diets.

Therefore, it can be concluded that the consumption of LEMS as food supplement may be considered a functional food for delay or protect risk of renal dysfunction.

We suggest that the anti-inflammatory and antioxidant properties of GM were dependent on the total phenolics and flavonoid contents of the LEMS.

Key words: - Nephrotoxicity, α LA, lemongrass, Gallic acid equivalents, Catechin equivalents.