Therapies for Prevention and Treatment of Alzheimer’s Disease
المؤلفون المشاركون
Berumen, Laura Cristina
Mendiola-Precoma, J.
Padilla, K.
Garcia-Alcocer, G.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-07-28
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Alzheimer’s disease (AD) is the most common cause of dementia associated with a progressive neurodegenerative disorder, with a prevalence of 44 million people throughout the world in 2015, and this figure is estimated to double by 2050.
This disease is characterized by blood-brain barrier disruption, oxidative stress, mitochondrial impairment, neuroinflammation, and hypometabolism; it is related to amyloid-β peptide accumulation and tau hyperphosphorylation as well as a decrease in acetylcholine levels and a reduction of cerebral blood flow.
Obesity is a major risk factor for AD, because it induces adipokine dysregulation, which consists of the release of the proinflammatory adipokines and decreased anti-inflammatory adipokines, among other processes.
The pharmacological treatments for AD can be divided into two categories: symptomatic treatments such as acetylcholinesterase inhibitors and N-methyl-D-aspartate (NMDA) receptor antagonists and etiology-based treatments such as secretase inhibitors, amyloid binders, and tau therapies.
Strategies for prevention of AD through nonpharmacological treatments are associated with lifestyle interventions such as exercise, mental challenges, and socialization as well as caloric restriction and a healthy diet.
AD is an important health issue on which all people should be informed so that prevention strategies that minimize the risk of its development may be implemented.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mendiola-Precoma, J.& Berumen, Laura Cristina& Padilla, K.& Garcia-Alcocer, G.. 2016. Therapies for Prevention and Treatment of Alzheimer’s Disease. BioMed Research International،Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1097113
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mendiola-Precoma, J.…[et al.]. Therapies for Prevention and Treatment of Alzheimer’s Disease. BioMed Research International No. 2016 (2016), pp.1-17.
https://search.emarefa.net/detail/BIM-1097113
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mendiola-Precoma, J.& Berumen, Laura Cristina& Padilla, K.& Garcia-Alcocer, G.. Therapies for Prevention and Treatment of Alzheimer’s Disease. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1097113
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1097113
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر