Microbial and Natural Metabolites That Inhibit Splicing: A Powerful Alternative for Cancer Treatment
المؤلفون المشاركون
Martínez-Montiel, Nancy
Rosas-Murrieta, Nora Hilda
Martínez-Montiel, Mónica
Gaspariano-Cholula, Mayra Patricia
Martínez-Contreras, Rebeca D.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-16
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
In eukaryotes, genes are frequently interrupted with noncoding sequences named introns.
Alternative splicing is a nuclear mechanism by which these introns are removed and flanking coding regions named exons are joined together to generate a message that will be translated in the cytoplasm.
This mechanism is catalyzed by a complex machinery known as the spliceosome, which is conformed by more than 300 proteins and ribonucleoproteins that activate and regulate the precision of gene expression when assembled.
It has been proposed that several genetic diseases are related to defects in the splicing process, including cancer.
For this reason, natural products that show the ability to regulate splicing have attracted enormous attention due to its potential use for cancer treatment.
Some microbial metabolites have shown the ability to inhibit gene splicing and the molecular mechanism responsible for this inhibition is being studied for future applications.
Here, we summarize the main types of natural products that have been characterized as splicing inhibitors, the recent advances regarding molecular and cellular effects related to these molecules, and the applications reported so far in cancer therapeutics.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Martínez-Montiel, Nancy& Rosas-Murrieta, Nora Hilda& Martínez-Montiel, Mónica& Gaspariano-Cholula, Mayra Patricia& Martínez-Contreras, Rebeca D.. 2016. Microbial and Natural Metabolites That Inhibit Splicing: A Powerful Alternative for Cancer Treatment. BioMed Research International،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1097402
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Martínez-Montiel, Nancy…[et al.]. Microbial and Natural Metabolites That Inhibit Splicing: A Powerful Alternative for Cancer Treatment. BioMed Research International No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1097402
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Martínez-Montiel, Nancy& Rosas-Murrieta, Nora Hilda& Martínez-Montiel, Mónica& Gaspariano-Cholula, Mayra Patricia& Martínez-Contreras, Rebeca D.. Microbial and Natural Metabolites That Inhibit Splicing: A Powerful Alternative for Cancer Treatment. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1097402
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1097402
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر