Expression of HIF-2α and VEGF in Cervical Squamous Cell Carcinoma and Its Clinical Significance
المؤلفون المشاركون
Zhang, Lixia
Chen, Qiang
Hu, Jing
Chen, Yue
Liu, Chenglong
Xu, Changshui
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-20
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
CSCC is a systemic disease involving polygenic alteration and multiple steps, and HIF and VEGF are closely associated with tumorigenesis.
Specimens surgically resected from 64 cases of CSCC and 22 cases of normal cervical tissue were selected randomly to detect the expression of HIF-2α and VEGF in CSCC for exploring their clinical significance; information regarding the age, lymph node metastasis, and FIGO staging were collected as well; expression of HIF-2α and VEGF was detected by qPCR and immunohistochemistry.
We found that the expression of HIF-2α and VEGF mRNA in CSCC was significantly higher than that of normal cervical tissues and showed a positive correlation between them.
The positive rates of HIF-2α and VEGF protein expression in CSCC and normal cervical tissues were 93.8% and 18.2%, respectively, with correlation between them.
The expression of both HIF-2α and VEGF mRNA did not relate closely to age but the FIGO staging and lymph node metastasis.
Compared with the counterpart control group, CSCC tissues with high FIGO staging and lymph node metastasis had a higher level of HIF-2α and VEGF mRNA expression.
So, HIF-2α and VEGF were overexpressed in CSCC, which has a great clinical significance for its diagnosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Lixia& Chen, Qiang& Hu, Jing& Chen, Yue& Liu, Chenglong& Xu, Changshui. 2016. Expression of HIF-2α and VEGF in Cervical Squamous Cell Carcinoma and Its Clinical Significance. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098155
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Lixia…[et al.]. Expression of HIF-2α and VEGF in Cervical Squamous Cell Carcinoma and Its Clinical Significance. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1098155
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Lixia& Chen, Qiang& Hu, Jing& Chen, Yue& Liu, Chenglong& Xu, Changshui. Expression of HIF-2α and VEGF in Cervical Squamous Cell Carcinoma and Its Clinical Significance. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098155
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1098155
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر