Homocysteine Levels in Parkinson’s Disease: Is Entacapone Effective?
المؤلفون المشاركون
Kocer, Bilge
Guven, Hayat
Comoglu, Selim Selcuk
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-07-17
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Plasma homocysteine (Hcy) levels may increase in levodopa-treated patients with Parkinson’s disease (PD) as a consequence of levodopa methylation via catechol-O-methyltransferase (COMT).
Results from previous studies that assessed the effect of COMT inhibitors on levodopa-induced hyperhomocysteinemia are conflicting.
We aimed to evaluate the effects of levodopa and entacapone on plasma Hcy levels.
A hundred PD patients were enrolled to the study and divided into three treatment groups (group I: levodopa and/or dopamine agonists; group II: levodopa, entacapone, and/or a dopamine agonist; and group III: dopamine agonist alone).
We measured the serum B12, folic acid, and Hcy levels in all patients.
There were no statistically significant differences between groups in terms of modified Hoehn and Yahr stages, Unified Parkinson’s Disease Rating Scale II/III, Standardized Mini-Mental Test scores, and serum vitamin B12 and folic acid levels.
Plasma median Hcy levels were found above the normal laboratory values in groups I and II, but they were normal in group III.
However, there was no statistically significant difference in plasma Hcy levels between groups.
Our results showed that levodopa treatment may cause a slight increase in the Hcy levels in PD compared with dopamine agonists and that COMT inhibitors may not have a significant effect on preventing hyperhomocysteinemia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kocer, Bilge& Guven, Hayat& Comoglu, Selim Selcuk. 2016. Homocysteine Levels in Parkinson’s Disease: Is Entacapone Effective?. BioMed Research International،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1098819
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kocer, Bilge…[et al.]. Homocysteine Levels in Parkinson’s Disease: Is Entacapone Effective?. BioMed Research International No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1098819
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kocer, Bilge& Guven, Hayat& Comoglu, Selim Selcuk. Homocysteine Levels in Parkinson’s Disease: Is Entacapone Effective?. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1098819
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1098819
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر