Development of a Murine Infection Model with Leishmania killicki, Responsible for Cutaneous Leishmaniosis in Algeria: Application in Pharmacology
المؤلفون المشاركون
Eddaikra, Naouel
Kherachi Djenad, Ihcene
Benbetka, Sihem
Benikhlef, Razika
Aït-Oudhia, Khatima
Moulti-Mati, Farida
Oury, Bruno
Sereno, Denis
Harrat, Zoubir
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-02
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
In Algeria, Leishmania infantum, Leishmania major, and Leishmania killicki (Leishmania tropica) are responsible for cutaneous leishmaniosis.
We established a murine model of L.
killicki infection to investigate its infective capacity, some immunophysiopathological aspects, and its suitability for pharmacological purposes.
Following the injection of L.
major or L.
killicki metacyclic promastigotes in the ear dermis of BALB/c mice, the course of infection was followed.
The infection with L.
killicki caused slower lesion formation than with L.
major.
The presence of L.
killicki or L.
major DNA and parasites was detected in the ear dermis and in lymph nodes, spleen, and liver.
Lesions induced by L.
killicki were nonulcerative in their aspect, whereas those caused by L.
major were highly ulcerative and necrotic, which matches well with the lesion phenotype reported in humans for L.
killicki and L.
major, respectively.
The treatment of L.
killicki lesions by injection of Glucantime® significantly reduced the lesion thickness and parasite burden.
Ear dermal injection of BALB/c mice constitutes a model to study lesions physiopathology caused by L.
killicki and presents interest for in vivo screening of new compounds against this pathogen, emerging in Algeria.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Eddaikra, Naouel& Kherachi Djenad, Ihcene& Benbetka, Sihem& Benikhlef, Razika& Aït-Oudhia, Khatima& Moulti-Mati, Farida…[et al.]. 2016. Development of a Murine Infection Model with Leishmania killicki, Responsible for Cutaneous Leishmaniosis in Algeria: Application in Pharmacology. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098901
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Eddaikra, Naouel…[et al.]. Development of a Murine Infection Model with Leishmania killicki, Responsible for Cutaneous Leishmaniosis in Algeria: Application in Pharmacology. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1098901
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Eddaikra, Naouel& Kherachi Djenad, Ihcene& Benbetka, Sihem& Benikhlef, Razika& Aït-Oudhia, Khatima& Moulti-Mati, Farida…[et al.]. Development of a Murine Infection Model with Leishmania killicki, Responsible for Cutaneous Leishmaniosis in Algeria: Application in Pharmacology. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098901
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1098901
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر