Polymorphisms in DNA Repair Gene XRCC3 and Susceptibility to Breast Cancer in Saudi Females
المؤلفون المشاركون
Ali Khan Pathan, Akbar
Alanazi, Mohammed
Alabdulkarim, Huda A.
Alamri, Abdullah
Ali, Alaa Mohammed
Purusottapatnam Shaik, Jilani
Warsy, Arjumand
Reddy Parine, Narasimha
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-06
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
We investigated three common polymorphisms (SNPs) in the XRCC3 gene (rs861539, rs1799794, and rs1799796) in 143 Saudi females suffering from breast cancer (median age = 51.4 years) and 145 age matched normal healthy controls.
DNA was extracted from whole blood and genotyping was conducted using PCR-RFLP.
rs1799794 showed significant association, where AA and AA+AG occurred at a significantly higher frequency in the cancer patients compared to the control group (OR: 28.1; 95% CI: 3.76–21.12; χ 2 : 22.82; p < 0.0001 ).
The G allele was protective and presented with a dominant model.
The genotype and allele frequencies of rs861539 C>T and rs1799796 A>G did not show a significant difference when the results in the patients and controls were compared.
However, the frequency of rs1799796 differed significantly in patients with different age of diagnosis, tumor grade, and ER and HER2 status.
The wild type A allele occurred at a higher frequency in the ER− and HER2− group.
Our results among Saudis suggest that some variations in XRCC3 may contribute to breast cancer susceptibility.
In conclusion, the results obtained during this study suggest that rs1799794 in XRCC3 shows strong association with breast cancer development in Saudi females.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ali, Alaa Mohammed& Alabdulkarim, Huda A.& Alanazi, Mohammed& Reddy Parine, Narasimha& Purusottapatnam Shaik, Jilani& Alamri, Abdullah…[et al.]. 2016. Polymorphisms in DNA Repair Gene XRCC3 and Susceptibility to Breast Cancer in Saudi Females. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1099128
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ali, Alaa Mohammed…[et al.]. Polymorphisms in DNA Repair Gene XRCC3 and Susceptibility to Breast Cancer in Saudi Females. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1099128
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ali, Alaa Mohammed& Alabdulkarim, Huda A.& Alanazi, Mohammed& Reddy Parine, Narasimha& Purusottapatnam Shaik, Jilani& Alamri, Abdullah…[et al.]. Polymorphisms in DNA Repair Gene XRCC3 and Susceptibility to Breast Cancer in Saudi Females. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1099128
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1099128
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر