The Expression of Osteopontin and Wnt5a in Articular Cartilage of Patients with Knee Osteoarthritis and Its Correlation with Disease Severity
المؤلفون المشاركون
Li, Yusheng
Deng, Zhenhan
Zeng, Chao
Li, Liangjun
Luo, Wei
Lei, Guanghua
Xiao, Wenfeng
Sun, Minghua
Li, Hui
Yang, Tuo
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-07-31
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objectives.
This study is undertaken to investigate the relation between osteopontin (OPN) and Wnt5a expression in the progression and pathogenesis of osteoarthritis (OA).
Methods.
50 cartilage tissues from knee OA patients and normal controls were divided into four groups of severe, moderate, minor, and normal lesions based on the modified grading system of Mankin.
Immunohistochemistry and real-time PCR were utilized to analyze the OPN and Wnt5a expression in articular cartilage.
Besides, the relations between OPN and Wnt5a expression and the severity of OA were explored.
Results.
OPN and Wnt5a could be identified in four groups’ tissues.
Amongst the groups, the intercomparisons of OPN expression levels showed statistical differences ( P < 0.01 ).
Besides, the intercomparisons of Wnt5a expression degrees showed statistical differences ( P < 0.05 ), except that between the minor and normal groups ( P > 0.05 ).
The scores of Mankin were demonstrated to relate to OPN expression ( r = - 0.847 , P < 0.01 ) and Wnt5a expression in every group ( r = - 0.843 , P < 0.01 ).
Also, a positive correlation can be observed between the OPN and Wnt5a expression ( r = 0.769 , P < 0.01 ).
Conclusion.
In articular cartilage, the expressions of OPN and Wnt5a are positively related to progressive damage of knee OA joint.
The correlation between Wnt5a and OPN might be important to the progression and pathogenesis of knee OA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Yusheng& Xiao, Wenfeng& Sun, Minghua& Deng, Zhenhan& Zeng, Chao& Li, Hui…[et al.]. 2016. The Expression of Osteopontin and Wnt5a in Articular Cartilage of Patients with Knee Osteoarthritis and Its Correlation with Disease Severity. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1099320
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Yusheng…[et al.]. The Expression of Osteopontin and Wnt5a in Articular Cartilage of Patients with Knee Osteoarthritis and Its Correlation with Disease Severity. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1099320
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Yusheng& Xiao, Wenfeng& Sun, Minghua& Deng, Zhenhan& Zeng, Chao& Li, Hui…[et al.]. The Expression of Osteopontin and Wnt5a in Articular Cartilage of Patients with Knee Osteoarthritis and Its Correlation with Disease Severity. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1099320
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1099320
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر