Impact of Rosuvastatin Treatment on HDL-Induced PKC-βII and eNOS Phosphorylation in Endothelial Cells and Its Relation to Flow-Mediated Dilatation in Patients with Chronic Heart Failure
المؤلفون المشاركون
Adams, Volker
Fischer, Tina
Schuler, Gerhard
Winzer, Ephraim B.
Gaida, Pauline
Höllriegel, Robert
Linke, Axel
Erbs, Sandra
المصدر
Cardiology Research and Practice
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-02
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Endothelial function is impaired in chronic heart failure (CHF).
Statins upregulate endothelial NO synthase (eNOS) and improve endothelial function.
Recent studies demonstrated that HDL stimulates NO production due to eNOS phosphorylation at Ser1177, dephosphorylation at Thr495, and diminished phosphorylation of PKC-βII at Ser660.
The aim of this study was to elucidate the impact of rosuvastatin on HDL mediated eNOS and PKC-βII phosphorylation and its relation to endothelial function.
Methods.
18 CHF patients were randomized to 12 weeks of rosuvastatin or placebo.
At baseline, 12 weeks, and 4 weeks after treatment cessation we determined lipid levels and isolated HDL.
Human aortic endothelial cells (HAEC) were incubated with isolated HDL and phosphorylation of eNOS and PKC-βII was evaluated.
Flow-mediated dilatation (FMD) was measured at the radial artery.
Results.
Rosuvastatin improved FMD significantly.
This effect was blunted after treatment cessation.
LDL plasma levels were reduced after rosuvastatin treatment whereas drug withdrawal resulted in significant increase.
HDL levels remained unaffected.
Incubation of HAEC with HDL had no impact on phosphorylation of eNOS or PKC-βII.
Conclusion.
HDL mediated eNOS and PKC-βII phosphorylation levels in endothelial cells do not change with rosuvastatin in CHF patients and do not mediate the marked improvement in endothelial function.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Winzer, Ephraim B.& Gaida, Pauline& Höllriegel, Robert& Fischer, Tina& Linke, Axel& Schuler, Gerhard…[et al.]. 2016. Impact of Rosuvastatin Treatment on HDL-Induced PKC-βII and eNOS Phosphorylation in Endothelial Cells and Its Relation to Flow-Mediated Dilatation in Patients with Chronic Heart Failure. Cardiology Research and Practice،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1103289
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Winzer, Ephraim B.…[et al.]. Impact of Rosuvastatin Treatment on HDL-Induced PKC-βII and eNOS Phosphorylation in Endothelial Cells and Its Relation to Flow-Mediated Dilatation in Patients with Chronic Heart Failure. Cardiology Research and Practice No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1103289
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Winzer, Ephraim B.& Gaida, Pauline& Höllriegel, Robert& Fischer, Tina& Linke, Axel& Schuler, Gerhard…[et al.]. Impact of Rosuvastatin Treatment on HDL-Induced PKC-βII and eNOS Phosphorylation in Endothelial Cells and Its Relation to Flow-Mediated Dilatation in Patients with Chronic Heart Failure. Cardiology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1103289
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1103289
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر