![](/images/graphics-bg.png)
Influence of βS-Globin Haplotypes and Hydroxyurea on Arginase I Levels in Sickle Cell Disease
المؤلفون المشاركون
Moreira, J. A.
Machado, R. P. G.
Laurentino, M. R.
Lemes, Romelia Pinheiro Gonçalves
Barbosa, M. C.
Santos, T. E.
Bandeira, I. C. J.
Martins, Alice Maria Costa
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-05-04
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Introduction.
Sickle cell disease (SCD) is characterized by hemoglobin S homozygosity, leading to hemolysis and vasoocclusion.
The hemolysis releases arginase I, an enzyme that decreases the bioavailability of nitric oxide, worsening the symptoms.
The different SCD haplotypes are related to clinical symptoms and varied hemoglobin F (HbF) concentration.
The aim of this study was to evaluate the impact of the βS gene haplotypes and HbF concentration on arginase I levels in SCD patients.
Methods.
Fifty SCD adult patients were enrolled in the study and 20 blood donors composed the control group.
Arginase I was measured by ELISA.
The βS haplotypes were identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
Statistical analyses were performed with GraphPad Prism program and the significance level was p < 0.05 .
Results.
Significant increase was observed in the arginase I levels in SCD patients compared to the control group ( p < 0.0001 ).
The comparison between the levels of arginase I in three haplotypes groups showed a difference between the Bantu/Bantu × Bantu/Benin groups; Bantu/Bantu × Benin/Benin, independent of HU dosage.
An inverse correlation with the arginase I levels and HbF concentration was observed.
Conclusion.
The results support the hypothesis that arginase I is associated with HbF concentration, also measured indirectly by the association with haplotypes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Moreira, J. A.& Machado, R. P. G.& Laurentino, M. R.& Lemes, Romelia Pinheiro Gonçalves& Barbosa, M. C.& Santos, T. E.…[et al.]. 2016. Influence of βS-Globin Haplotypes and Hydroxyurea on Arginase I Levels in Sickle Cell Disease. Disease Markers،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1103806
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Moreira, J. A.…[et al.]. Influence of βS-Globin Haplotypes and Hydroxyurea on Arginase I Levels in Sickle Cell Disease. Disease Markers No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1103806
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Moreira, J. A.& Machado, R. P. G.& Laurentino, M. R.& Lemes, Romelia Pinheiro Gonçalves& Barbosa, M. C.& Santos, T. E.…[et al.]. Influence of βS-Globin Haplotypes and Hydroxyurea on Arginase I Levels in Sickle Cell Disease. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1103806
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1103806
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)