Enhanced Absorption Study of Ginsenoside Compound K (20-O-β-(D-Glucopyranosyl)-20(S)-protopanaxadiol) after Oral Administration of Fermented Red Ginseng Extract (HYFRG™) in Healthy Korean Volunteers and Rats
المؤلفون المشاركون
Choi, Il-Dong
Ryu, Ju-Hee
Lee, Dong-Eun
Lee, Myoung-Hee
Shim, Jae-Joong
Ahn, Young-Tae
Sim, Jae-Hun
Huh, Chul-Sung
Shim, Wang-Seob
Yim, Sung-Vin
Chung, Eun-Kyoung
Lee, Kyung-Tae
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-07-19
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
To evaluate the pharmacokinetics of compound K after oral administration of HYFRG and RG in humans, an open-label, randomized, single-dose, fasting, and one-period pharmacokinetic study was conducted.
After oral administration of a single 3 g dose of HYFRG and RG to 24 healthy Korean males, the mean (±SD) of A U C 0 – t and C m a x of compound K from HYFRG were 1466.83 ± 295.89 ng · h/mL and 254.45 ± 51.20 ng/mL, being 115.2- and 80-fold higher than those for RG (12.73 ± 7.83 ng · h/mL and 3.18 ± 1.70 ng/mL), respectively; in case of Sprague Dawley rats the mean (±SD) of A U C 0 – t and C m a x of compound K from HYFRG was 58.03 ± 32.53 ng · h/mL and 15.19 ± 10.69 ng/mL, being 6.3- and 6.0-fold higher than those from RG (9.21 ± 7.52 ng · h/mL and 2.55 ± 0.99 ng/mL), respectively.
T m a x of compound K in humans and rats was 2.54 ± 0.92 and 3.33 ± 0.50 h for HYFRG and 9.11 ± 1.45 and 6.75 ± 3.97 hours for RG, respectively.
In conclusion, the administration of HYFRG resulted in a higher and faster absorption of compound K in both humans and rats compared to RG.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Choi, Il-Dong& Ryu, Ju-Hee& Lee, Dong-Eun& Lee, Myoung-Hee& Shim, Jae-Joong& Ahn, Young-Tae…[et al.]. 2016. Enhanced Absorption Study of Ginsenoside Compound K (20-O-β-(D-Glucopyranosyl)-20(S)-protopanaxadiol) after Oral Administration of Fermented Red Ginseng Extract (HYFRG™) in Healthy Korean Volunteers and Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104115
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Choi, Il-Dong…[et al.]. Enhanced Absorption Study of Ginsenoside Compound K (20-O-β-(D-Glucopyranosyl)-20(S)-protopanaxadiol) after Oral Administration of Fermented Red Ginseng Extract (HYFRG™) in Healthy Korean Volunteers and Rats. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1104115
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Choi, Il-Dong& Ryu, Ju-Hee& Lee, Dong-Eun& Lee, Myoung-Hee& Shim, Jae-Joong& Ahn, Young-Tae…[et al.]. Enhanced Absorption Study of Ginsenoside Compound K (20-O-β-(D-Glucopyranosyl)-20(S)-protopanaxadiol) after Oral Administration of Fermented Red Ginseng Extract (HYFRG™) in Healthy Korean Volunteers and Rats. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104115
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104115
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر