Identification of Centella asiatica’s Effective Ingredients for Inducing the Neuronal Differentiation
المؤلفون المشاركون
Jiang, Hui
Zheng, Guoshuai
Lv, Junwei
Chen, Heyu
Lin, Jinjin
Li, Yiyang
Fan, Guorong
Ding, Xianting
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-30
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Centella asiatica, commonly known as Gotu kola, has been widely used as a traditional herb for decades.
Yet, the study on which compounds or compound combinations actually lead to its brain benefits remains scarce.
To study the neuroprotection effects of Centella asiatica, neuronal differentiation of PC12 cells was applied.
In our pilot study, we isolated 45 Centella asiatica fractions and tested their abilities for inducing neuronal differentiation on PC12 cells.
The most effective fraction showed robust induction in neurite outgrowth and neurofilament expression.
LC-MS fingerprint analysis of this fraction revealed asiatic acid and madecassic acid as the dominant components.
A further investigation on the pure combination of these two compounds indicated that the combination of these two compounds extensively promoted nerve differentiation in vitro.
Application of PD98059, a protein MEK inhibitor, attenuated combination-induced neurofilament expression, indicating the combination-induced nerve differentiation through activation of MEK signaling pathway.
Our results support the use of combination of asiatic acid and madecassic acid as an effective mean to intervene neurodegenerative diseases in which neurotrophin deficiency is involved.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jiang, Hui& Zheng, Guoshuai& Lv, Junwei& Chen, Heyu& Lin, Jinjin& Li, Yiyang…[et al.]. 2016. Identification of Centella asiatica’s Effective Ingredients for Inducing the Neuronal Differentiation. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104523
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jiang, Hui…[et al.]. Identification of Centella asiatica’s Effective Ingredients for Inducing the Neuronal Differentiation. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1104523
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jiang, Hui& Zheng, Guoshuai& Lv, Junwei& Chen, Heyu& Lin, Jinjin& Li, Yiyang…[et al.]. Identification of Centella asiatica’s Effective Ingredients for Inducing the Neuronal Differentiation. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104523
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104523
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر