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In Vitro TNF-α Inhibitory Activity of Brazilian Plants and Anti-Inflammatory Effect of Stryphnodendron adstringens in an Acute Arthritis Model
المؤلفون المشاركون
Braga, Fernão Castro
Souza, Danielle Glória
Castilho, Rachel O.
Henriques, Bárbara O.
Corrêa, Olívia
Azevedo, Elaine Patrícia C.
Oliveira, Vívian Louise S. de
Oliveira, Thiago Henrique C.
Boff, Daiane
Dias, Ana Carolina F.
Amaral, Flávio A.
Teixeira, Mauro Martins
Pádua, Rodrigo Maia de
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-27
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Stryphnodendron species, popularly named “barbatimão,” are traditionally used in Brazil as anti-inflammatory agents.
This study aimed to investigate the effect of barbatimão and 11 other species on the production of tumor necrosis factor-alpha (TNF-α) in lipopolysaccharide- (LPS-) stimulated THP-1 cells, as well as their anti-arthritis activity.
The extracts of Stryphnodendron adstringens, Stryphnodendron obovatum, Campomanesia lineatifolia, and Terminalia glabrescens promoted a concentration-dependent inhibition of TNF-α.
Mice injected with LPS in the knee joint were treated per os with fractions from the selected extracts.
Both the organic (SAO) and the aqueous (SAA) fractions of S.
adstringens promoted a dose-dependent reduction of leukocyte migration and neutrophil accumulation into the joint, but none of them reduced CXCL1 concentration in the periarticular tissue.
In contrast, treatment with C.
lineatifolia and T.
glabrescens fractions did not ameliorate the inflammatory parameters.
Analyses of SAO by Ultra Performance Liquid Chromatography (UPLC) coupled to electrospray ionization mass spectrometry (ESI-MS) led to the identification of gallic acid along with 11 prodelphinidins, characterized as monomers and dimers of the B-type.
Our findings contribute to some extent to corroborating the traditional use of S.
adstringens as an anti-inflammatory agent.
This activity is probably related to a decrease of leukocyte migration into the inflammatory site.
Polyphenols like gallic acid and prodelphinidins, identified in the active fraction, may contribute to the observed activity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Henriques, Bárbara O.& Corrêa, Olívia& Azevedo, Elaine Patrícia C.& Pádua, Rodrigo Maia de& Oliveira, Vívian Louise S. de& Oliveira, Thiago Henrique C.…[et al.]. 2016. In Vitro TNF-α Inhibitory Activity of Brazilian Plants and Anti-Inflammatory Effect of Stryphnodendron adstringens in an Acute Arthritis Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1104539
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Henriques, Bárbara O.…[et al.]. In Vitro TNF-α Inhibitory Activity of Brazilian Plants and Anti-Inflammatory Effect of Stryphnodendron adstringens in an Acute Arthritis Model. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1104539
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Henriques, Bárbara O.& Corrêa, Olívia& Azevedo, Elaine Patrícia C.& Pádua, Rodrigo Maia de& Oliveira, Vívian Louise S. de& Oliveira, Thiago Henrique C.…[et al.]. In Vitro TNF-α Inhibitory Activity of Brazilian Plants and Anti-Inflammatory Effect of Stryphnodendron adstringens in an Acute Arthritis Model. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1104539
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104539
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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