The Effects of Infliximab on Laminin, NFκB, and Anti-TNF Expression through Its Effect on Ischemic Liver Tissue
المؤلفون المشاركون
Kalkan, Yildiray
Tümkaya, Levent
Rakıcı, Halil
Akdoğan, Elif
Akdoğan, Remzi Adnan
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-07
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
The aim of this study was to investigate the possible protective effects of infliximab on expression of laminin, anti-TNF, and NFκB in the rat hepatic cells after ischemia/reperfusion (I/R).
A total of 30 male Wistar albino rats were divided into three groups: Control (C), sham I/R (ISC), and I/R+ infliximab (ISC inf); each group comprised 10 animals.
C group animals underwent laparotomy without I/R injury.
In ISC groups after undergoing laparotomy, 1 hour of superior mesenteric artery ligation was done, which was followed by 1 hour of reperfusion.
In the ISC inf group, 3 days before I/R, infliximab (3 mg/kg) was administered intravenously.
All animals were killed at the end of reperfusion and hepatic tissue samples were obtained for histopathological and histochemical investigations in all groups.
Laminin, anti-TNF, and NFκB immunoreactivity were performed for all groups.
ISC caused severe histopathological injury including mucosal erosions, inflammatory cell infiltration, necrosis, hemorrhage, and villous congestion.
Infliximab treatment significantly attenuated the severity of intestinal I/R injury and it is shown by laminin, anti-TNF, and NFκB immunoreactivity.
Because of its anti-inflammatory and antioxidant effects, infliximab pretreatment may have protective effects on hepatic cells in the experimental intestinal I/R model of rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Akdoğan, Remzi Adnan& Kalkan, Yildiray& Tümkaya, Levent& Rakıcı, Halil& Akdoğan, Elif. 2016. The Effects of Infliximab on Laminin, NFκB, and Anti-TNF Expression through Its Effect on Ischemic Liver Tissue. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1104598
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Akdoğan, Remzi Adnan…[et al.]. The Effects of Infliximab on Laminin, NFκB, and Anti-TNF Expression through Its Effect on Ischemic Liver Tissue. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1104598
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Akdoğan, Remzi Adnan& Kalkan, Yildiray& Tümkaya, Levent& Rakıcı, Halil& Akdoğan, Elif. The Effects of Infliximab on Laminin, NFκB, and Anti-TNF Expression through Its Effect on Ischemic Liver Tissue. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1104598
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104598
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر