Connexin’s Connection in Breast Cancer Growth and Progression
المؤلف
المصدر
International Journal of Cell Biology
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-23
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Gap junctions are cell-to-cell junctions that are located in the basolateral surface of two adjoining cells.
A gap junction channel is composed of a family of proteins called connexins.
Gap junction channels maintain intercellular communication between two cells through the exchange of ions, small metabolites, and electrical signals.
Gap junction channels or connexins are widespread in terms of their expression and function in maintaining the development, differentiation, and homeostasis of vertebrate tissues.
Gap junction connexins play a major role in maintaining intercellular communication among different cell types of normal mammary gland for proper development and homeostasis.
Connexins have also been implicated in the pathogenesis of breast cancer.
Differential expression pattern of connexins and their gap junction dependent or independent functions provide pivotal cross talk of breast tumor cells with the surrounding stromal cell in the microenvironment.
Substantial research from the last 20 years has accumulated ample evidences that allow us a better understanding of the roles that connexins play in the tumorigenesis of primary breast tumor and its metastatic progression.
This review will summarize the knowledge about the connexins and gap junction activities in breast cancer highlighting the differential expression and functional dynamics of connexins in the pathogenesis of the disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Banerjee, Debarshi. 2016. Connexin’s Connection in Breast Cancer Growth and Progression. International Journal of Cell Biology،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1105508
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Banerjee, Debarshi. Connexin’s Connection in Breast Cancer Growth and Progression. International Journal of Cell Biology No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1105508
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Banerjee, Debarshi. Connexin’s Connection in Breast Cancer Growth and Progression. International Journal of Cell Biology. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1105508
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1105508
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر