Influence of Androgen Receptor Gene CAG and GGC Polymorphisms on Male Sexual Function: A Cross-Sectional Study

المؤلفون المشاركون

Tirabassi, Giacomo
Maggi, Mario
delli Muti, Nicola
Corona, Giovanni
Balercia, Giancarlo
Falzetti, Sara

المصدر

International Journal of Endocrinology

العدد

المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2016-12-15

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الأحياء

الملخص EN

Background.

No study has assessed the possible involvement of GGC androgen receptor (AR) polymorphism in sexual function.

Our aim is to evaluate the association between CAG and GGC AR polymorphisms in this function.

Methods.

We retrospectively examined eighty-five outpatients.

Clinical, biochemical, and genetic parameters were considered.

Sexual assessment was performed using the International Index of Erectile Function (IIEF) which evaluates erectile function (EF), orgasmic function (OF), sexual desire (SD), intercourse satisfaction (IS), and overall satisfaction (OS).

Results.

In the whole sample, CAG repeats were inversely correlated with EF, OF, and total IIEF-15 score, whereas GGC tracts did not show any significant correlation with sexual function.

CAG relationship with IIEF items retained significance only in the eugonadal but not in the hypogonadal cohort.

On the other hand, GGC tracts were not found to be significantly correlated with IIEF variables in either eugonadal or hypogonadal subjects.

In eugonadal subjects, logistic regression pointed out that a higher number of CAG triplets were associated with lower values of EF, OF, SD, OS, and total IIEF independently from other confounders.

Conclusions.

GGC polymorphism seems not to exert any influence on sexual function, whereas CAG polymorphism appears to affect sexual parameters only in eugonadal subjects.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Tirabassi, Giacomo& Corona, Giovanni& Falzetti, Sara& delli Muti, Nicola& Maggi, Mario& Balercia, Giancarlo. 2016. Influence of Androgen Receptor Gene CAG and GGC Polymorphisms on Male Sexual Function: A Cross-Sectional Study. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1105902

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Tirabassi, Giacomo…[et al.]. Influence of Androgen Receptor Gene CAG and GGC Polymorphisms on Male Sexual Function: A Cross-Sectional Study. International Journal of Endocrinology No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1105902

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Tirabassi, Giacomo& Corona, Giovanni& Falzetti, Sara& delli Muti, Nicola& Maggi, Mario& Balercia, Giancarlo. Influence of Androgen Receptor Gene CAG and GGC Polymorphisms on Male Sexual Function: A Cross-Sectional Study. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1105902

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1105902