The Association of Peroxisome Proliferator-Activated Receptor δ and Additional Gene-Gene Interaction with C-Reactive Protein in Chinese Population
المؤلفون المشاركون
Ding, Xiao-Ying
Yuan, Hao-Zheng
Gu, Ru
Gao, Yan-Feng
Liu, Xiao-Gang
Gao, Ya
المصدر
International Journal of Endocrinology
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-13
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Aims.
To examine the association between 4 single nucleotide polymorphisms (SNPs) of peroxisome proliferator-activated receptors δ (PPARδ) polymorphisms and C-reactive protein (CRP) level and additional gene-gene interaction.
Methods.
Line regression analysis was performed to verify polymorphism association between SNP and CRP levels.
Generalized multifactor dimensionality reduction (GMDR) was employed to analyze the interaction.
Results.
A total of 1028 subjects (538 men, 490 women) were selected.
The carriers of the C allele (TC or CC) of rs2016520 were associated with a significant decreased level of CRP, regression coefficients was −0.338, and standard error was 0.104 ( p = 0.001 ).
The carriers of the G allele (CG or GG) of rs9794 were also significantly associated with decreased level of CRP, regression coefficients was −0.219, and standard error was 0.114 ( p = 0.012 ).
We also found a potential gene-gene interaction between rs2016520 and rs9794.
Subjects with rs2016520-TC or CC, rs9794-CG or GG genotypes have lowest CRP level, difference (95% CI) = −0.50 (−0.69 to −0.21) ( p < 0.001 ), compared to subjects with rs2016520-TT and rs9794-CC genotypes.
Conclusions.
rs2016520 and rs9794 minor allele of PPARδ and combined effect between the two SNP were associated with decreased CRP level.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ding, Xiao-Ying& Yuan, Hao-Zheng& Gu, Ru& Gao, Yan-Feng& Liu, Xiao-Gang& Gao, Ya. 2016. The Association of Peroxisome Proliferator-Activated Receptor δ and Additional Gene-Gene Interaction with C-Reactive Protein in Chinese Population. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1106034
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ding, Xiao-Ying…[et al.]. The Association of Peroxisome Proliferator-Activated Receptor δ and Additional Gene-Gene Interaction with C-Reactive Protein in Chinese Population. International Journal of Endocrinology No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1106034
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ding, Xiao-Ying& Yuan, Hao-Zheng& Gu, Ru& Gao, Yan-Feng& Liu, Xiao-Gang& Gao, Ya. The Association of Peroxisome Proliferator-Activated Receptor δ and Additional Gene-Gene Interaction with C-Reactive Protein in Chinese Population. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1106034
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1106034
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر