Methylglyoxal Impairs Insulin Secretion of Pancreatic β-Cells through Increased Production of ROS and Mitochondrial Dysfunction Mediated by Upregulation of UCP2 and MAPKs
المؤلفون المشاركون
Bo, Jinshuang
Xie, Shiya
Guo, Yi
Zhang, Chunli
Guan, Yanming
Li, Chunmei
Lu, Jianxin
Meng, Qing H.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-07
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Methylglyoxal (MG) is a highly reactive glucose metabolic intermediate and a major precursor of advanced glycation end products.
MG level is elevated in hyperglycemic disorders such as diabetes mellitus.
Substantial evidence has shown that MG is involved in the pathogenesis of diabetes and diabetic complications.
We investigated the impact of MG on insulin secretion by MIN6 and INS-1 cells and the potential mechanisms of this effect.
Our study demonstrates that MG impaired insulin secretion by MIN6 or ISN-1 cells in a dose-dependent manner.
It increased reactive oxygen species (ROS) production and apoptosis rate in MIN6 or ISN-1 cells and inhibited mitochondrial membrane potential (MMP) and ATP production.
Furthermore, the expression of UCP2, JNK, and P38 as well as the phosphorylation JNK and P38 was increased by MG.
These effects of MG were attenuated by MG scavenger N-acetyl cysteine.
Collectively, these data indicate that MG impairs insulin secretion of pancreatic β-cells through increasing ROS production.
High levels of ROS can damage β-cells directly via JNK/P38 upregulation and through activation of UCP2 resulting in reduced MMP and ATP production, leading to β-cell dysfunction and impairment of insulin production.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bo, Jinshuang& Xie, Shiya& Guo, Yi& Zhang, Chunli& Guan, Yanming& Li, Chunmei…[et al.]. 2015. Methylglyoxal Impairs Insulin Secretion of Pancreatic β-Cells through Increased Production of ROS and Mitochondrial Dysfunction Mediated by Upregulation of UCP2 and MAPKs. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1107997
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bo, Jinshuang…[et al.]. Methylglyoxal Impairs Insulin Secretion of Pancreatic β-Cells through Increased Production of ROS and Mitochondrial Dysfunction Mediated by Upregulation of UCP2 and MAPKs. Journal of Diabetes Research No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1107997
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bo, Jinshuang& Xie, Shiya& Guo, Yi& Zhang, Chunli& Guan, Yanming& Li, Chunmei…[et al.]. Methylglyoxal Impairs Insulin Secretion of Pancreatic β-Cells through Increased Production of ROS and Mitochondrial Dysfunction Mediated by Upregulation of UCP2 and MAPKs. Journal of Diabetes Research. 2015. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1107997
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1107997
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر