The Polymorphism −308GA of Tumor Necrosis Factor-α Gene Modulates the Effect of Immunosuppressive Treatment in First Kidney Transplant Subjects Who Suffer an Acute Rejection
المؤلفون المشاركون
Pérez-Flores, Isabel
Santiago, Jose Luis
Urcelay, Elena
Sánchez-Fructuoso, Ana Isabel
Valero, Rosalia
Moreno, Maria Angeles
Fernandez-Arquero, Miguel
Fernández-Pérez, Cristina
المصدر
Journal of Immunology Research
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-29
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The −308G/A SNP of tumor necrosis factor-alpha (TNF-α) gene affects TNF-α production.
As its impact on transplant outcome remains open to debate, we decided to genotype it in a cohort of transplant subjects.
A retrospective analysis of 439 first kidney recipients randomly divided into two subgroups (discovery and validation cohorts) was performed to identify the best predictors of acute rejection (AR).
The effect on transplant outcome was analyzed by an adjusted logistic regression model.
Carriers of the A allele, associated with elevated TNF-α production, presented a higher risk of AR (OR = 2.78; 95% CI = 1.40–5.51).
Logistic regression analyses for AR showed an interaction between the polymorphism and treatment with thymoglobulin (p-interaction = 0.03).
In recipients who did not receive thymoglobulin, carriers of A allele had higher risk of AR (OR = 4.05; 95% CI = 1.76–9.28).
Moreover, carriers of A allele not treated with thymoglobulin presented higher risk of AR than those who received thymoglobulin (OR = 13.74; 95% CI = 1.59–118.7).
The AUC of the model in the discovery cohort was 0.70 and in the validation cohort was 0.69.
Our findings indicate that the −308G/A TNF-α polymorphism is associated with AR risk and it modulates the effectiveness of thymoglobulin treatment.
This pharmacogenetic effect lets us propose this SNP as a useful predictor biomarker to tailor immunosuppressive regimens.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sánchez-Fructuoso, Ana Isabel& Pérez-Flores, Isabel& Valero, Rosalia& Moreno, Maria Angeles& Fernandez-Arquero, Miguel& Urcelay, Elena…[et al.]. 2016. The Polymorphism −308GA of Tumor Necrosis Factor-α Gene Modulates the Effect of Immunosuppressive Treatment in First Kidney Transplant Subjects Who Suffer an Acute Rejection. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1108731
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sánchez-Fructuoso, Ana Isabel…[et al.]. The Polymorphism −308GA of Tumor Necrosis Factor-α Gene Modulates the Effect of Immunosuppressive Treatment in First Kidney Transplant Subjects Who Suffer an Acute Rejection. Journal of Immunology Research No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1108731
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sánchez-Fructuoso, Ana Isabel& Pérez-Flores, Isabel& Valero, Rosalia& Moreno, Maria Angeles& Fernandez-Arquero, Miguel& Urcelay, Elena…[et al.]. The Polymorphism −308GA of Tumor Necrosis Factor-α Gene Modulates the Effect of Immunosuppressive Treatment in First Kidney Transplant Subjects Who Suffer an Acute Rejection. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1108731
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108731
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر