Immune Response Induced by an Immunodominant 60 kDa Glycoprotein of the Cell Wall of Sporothrix schenckii in Two Mice Strains with Experimental Sporotrichosis
المؤلفون المشاركون
López-Romero, Everardo
Alba-Fierro, Carlos A.
Pérez-Torres, Armando
Toriello, Conchita
Pulido-Camarillo, Evelyn
Romo-Lozano, Yolanda
Gutiérrez-Sánchez, Gerardo
Ruiz-Baca, Estela
المصدر
Journal of Immunology Research
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-14
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Cell wall (CW) components of fungus Sporothrix schenckii are the major inductors antigens of immune responses.
The immunodominant 60 kDa glycoprotein (gp60) has been shown to be associated with the virulence of this fungus but its role in experimental sporotrichosis is unknown.
In this work, the immunological effects of CW-purified gp60 were investigated in a model of experimental subcutaneous sporotrichosis in normal and gp60-preimmunized C57BL/6 and BALB/c mice strains which were then infected with S.
schenckii conidia.
Results showed that both mice strains use different cytokine profiles in order to fight S.
schenckii infection; C57BL/6 mice seem to use a Th17 response while BALB/c mice tend to depend on a Th1 profile.
Preimmunization with gp60 showed a downregulatory effect on the immune response since cytokines levels were diminished in both strains.
There were no significant differences in the magnitude of dorsoplantar inflammation between gp60-preimmunized and nonimmunized mice of both strains.
However, skin lesions due to the infection in gp60-preimmunized mice were more severe in BALB/c than in C57BL/6 mice, suggesting that the antigen exerts a higher downregulatory effect on the Th1 response.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Alba-Fierro, Carlos A.& Pérez-Torres, Armando& Toriello, Conchita& Pulido-Camarillo, Evelyn& López-Romero, Everardo& Romo-Lozano, Yolanda…[et al.]. 2016. Immune Response Induced by an Immunodominant 60 kDa Glycoprotein of the Cell Wall of Sporothrix schenckii in Two Mice Strains with Experimental Sporotrichosis. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1108846
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Alba-Fierro, Carlos A.…[et al.]. Immune Response Induced by an Immunodominant 60 kDa Glycoprotein of the Cell Wall of Sporothrix schenckii in Two Mice Strains with Experimental Sporotrichosis. Journal of Immunology Research No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1108846
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Alba-Fierro, Carlos A.& Pérez-Torres, Armando& Toriello, Conchita& Pulido-Camarillo, Evelyn& López-Romero, Everardo& Romo-Lozano, Yolanda…[et al.]. Immune Response Induced by an Immunodominant 60 kDa Glycoprotein of the Cell Wall of Sporothrix schenckii in Two Mice Strains with Experimental Sporotrichosis. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1108846
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108846
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر