Antigen-Specific IFN-γ Responses Correlate with the Activity of M. tuberculosis Infection but Are Not Associated with the Severity of Tuberculosis Disease
المؤلفون المشاركون
Lyadova, I. V.
Panteleev, A. V.
Sosunova, Ekaterina
Nikitina, Irina Yu.
Karpina, Natalya L.
Bagdasarian, Tatef R.
Burmistrova, Irina A.
Andreevskaya, Sofia N.
Chernousova, Larisa N.
Vasilyeva, Irina A.
المصدر
Journal of Immunology Research
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-30
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
IFN-γ is a key cytokine in antituberculosis (TB) defense.
However, how the levels of its secretion affect M.
tuberculosis (Mtb) infection is not clear.
We have analyzed associations between IFN-γ responses measured in QuantiFERON®-TB Gold In-tube (QFT) assay, TB disease severity, and Mtb infection activity.
TB severity was evaluated based on the results of radiological, microbiological, and clinical examinations.
Antigen-driven IFN-γ secretion did not correlate with TB severity.
Mitogen-induced IFN-γ secretion correlated inversely with the form of pulmonary pathology and the area of affected pulmonary tissue; the levels of spontaneous IFN-γ secretion correlated with patients’ age (r = 0.395, p = 0.001).
Mtb infection activity was evaluated based on radiological data of lung tissue infiltration, destruction, dissemination or calcification, and condensation.
The rate of positive QFT results and the levels of antigen-driven IFN-γ secretion increased in a row: patients with residual TB lesions < patients with low TB activity < patients with high TB activity.
Thus, antigen-driven IFN-γ secretion and QFT results did not associate with TB severity but associated with the infection activity.
The results suggest that quantitative parameters of IFN-γ secretion play a minor role in determining the course of TB disease but mirror the activity of the infectious process.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nikitina, Irina Yu.& Panteleev, A. V.& Sosunova, Ekaterina& Karpina, Natalya L.& Bagdasarian, Tatef R.& Burmistrova, Irina A.…[et al.]. 2016. Antigen-Specific IFN-γ Responses Correlate with the Activity of M. tuberculosis Infection but Are Not Associated with the Severity of Tuberculosis Disease. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1108867
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nikitina, Irina Yu.…[et al.]. Antigen-Specific IFN-γ Responses Correlate with the Activity of M. tuberculosis Infection but Are Not Associated with the Severity of Tuberculosis Disease. Journal of Immunology Research No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1108867
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nikitina, Irina Yu.& Panteleev, A. V.& Sosunova, Ekaterina& Karpina, Natalya L.& Bagdasarian, Tatef R.& Burmistrova, Irina A.…[et al.]. Antigen-Specific IFN-γ Responses Correlate with the Activity of M. tuberculosis Infection but Are Not Associated with the Severity of Tuberculosis Disease. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1108867
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108867
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر