Construction of a Nanodiamond–Tamoxifen Complex as a Breast Cancer Drug Delivery Vehicle
المؤلفون المشاركون
Landeros-Martínez, Linda-Lucila
Chavez-Flores, David
Orrantia-Borunda, E.
Flores-Holguín, Norma
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-27
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
According to the World Health Organization, breast cancer represents 16% of all cancer cases in women and is the second most common cancer.
In the past decades, the mortality among patients with metastasis breast cancer has been reduced significantly via drug delivery by means of nanodiamond therapies, which are both biocompatible and scalable.
In this study, we determined a theoretical pathway for the construction of a nanodiamond–tamoxifen complex that will act as a drug delivery vehicle for targeting tumor tissues of breast cancer.
The tamoxifen pharmacophore was defined and the binding zone was identified for the electrostatic interaction between tamoxifen and a functionalized site of a nanodiamond particle allowing for attachment of the payload (this drug) to the surface of the nanodiamond particle.
In addition, an analysis of the intermolecular interaction between the nanodiamond and tamoxifen was conducted, showing three hydrogen bonds complying fully with Lipinski’s rule of five, which states that a compound should have five or fewer hydrogen bonds to be permeating and easily absorbed by the body (qualitative prediction).
All calculations were performed using the conceptual Density Functional Theory with the M06 functional and the basis set 6-31G(d).
The solvent effect has been taken into account by an implicit model, the conductor like polarizable continuum model.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Landeros-Martínez, Linda-Lucila& Chavez-Flores, David& Orrantia-Borunda, E.& Flores-Holguín, Norma. 2016. Construction of a Nanodiamond–Tamoxifen Complex as a Breast Cancer Drug Delivery Vehicle. Journal of Nanomaterials،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1109070
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Landeros-Martínez, Linda-Lucila…[et al.]. Construction of a Nanodiamond–Tamoxifen Complex as a Breast Cancer Drug Delivery Vehicle. Journal of Nanomaterials No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1109070
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Landeros-Martínez, Linda-Lucila& Chavez-Flores, David& Orrantia-Borunda, E.& Flores-Holguín, Norma. Construction of a Nanodiamond–Tamoxifen Complex as a Breast Cancer Drug Delivery Vehicle. Journal of Nanomaterials. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1109070
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1109070
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر